Early decline in the catecholamine release-inhibitory peptide catestatin in humans at genetic risk of hypertension.
- 1 July 2002
- journal article
- clinical trial
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal Of Hypertension
- Vol. 20 (7), 1335-1345
- https://doi.org/10.1097/00004872-200207000-00020
Abstract
Hypertension is a complex trait with an ill-defined genetic predisposition, in which adrenergic mechanisms seem to be involved even at the early stages. Chromogranin A is a pro-hormone stored and released with catecholamines by exocytosis; its fragment catestatin, formed in vivo, inhibits further catecholamine release as an antagonist at the physiologic trigger for secretion, the neuronal nicotinic cholinergic receptor. We measured catestatin by radioimmunoassay in n = 277 subjects stratified by blood pressure (n = 61 hypertensive, n = 216 normotensive), and if normotensive by genetic risk of developing hypertension: family history positive (n = 176) versus negative (n = 40). Maximum likelihood analysis tested for bimodality. Involvement of catestatin in pathophysiology was probed by measurements of catecholamines and leptin, and the hemodynamic responses to environmental (cold) stress. The normotensive offspring of patients with hypertension already had diminished catestatin (P = 0.024), and family history was a better predictor of catestatin than age, ethnicity or gender (P = 0.014). Greater catestatin variance among family history-positive individuals (P = 0.021) suggested heterogeneity in this group, and a bimodal distribution (PConclusions We conclude that catestatin is diminished early in the course of development of hypertension, even in the normotensive offspring of patients with the disease. Low catestatin predicts augmented adrenergic pressor responses, suggesting a mechanism whereby diminished catestatin might increase the risk for later development of hypertension.Keywords
This publication has 41 references indexed in Scilit:
- Formation of the Catecholamine Release-inhibitory Peptide Catestatin from Chromogranin APublished by Elsevier BV ,2000
- Leptin—Much More Than a Satiety SignalAnnual Review of Nutrition, 2000
- Leptin Directly Stimulates Catecholamine Secretion and Synthesis in Cultured Porcine Adrenal Medullary Chromaffin CellsBiochemical and Biophysical Research Communications, 1999
- Corrigendum to: The role of the sympathetic nervous system in the regulation of leptin synthesis in C57BL/6 mice (FEBS 21523)FEBS Letters, 1999
- Obesity-Induced HypertensionHypertension, 1999
- Hereditary intermediate phenotypes in African American hypertensionEthnicity & Health, 1996
- Chromogranin A in Human HypertensionHypertension, 1995
- Divergent Effects of Dihydropyridine and Phenylalkylamine Calcium Channel Antagonist Classes on Autonomic Function in Human HypertensionHypertension, 1995
- Chromogranin A. Storage and release in hypertension.Hypertension, 1990
- Pressor response to norepinephrine in essential hypertension. A study in families.Hypertension, 1990