Liver-specific microRNA-122: Biogenesis and function
Top Cited Papers
Open Access
- 1 February 2012
- journal article
- review article
- Published by Taylor & Francis Ltd in RNA Biology
- Vol. 9 (2), 137-142
- https://doi.org/10.4161/rna.18827
Abstract
MicroRNA-122 (miR-122) was one of the first examples of a tissue-specific miRNA. It is highly expressed in liver, where it constitutes 70% of the total miRNA pool. miR-122 expression is specific to the vertebrate lineage, where the sequence of the mature miRNA is completely conserved. miR-122 is a target for extensive study due to its association with cholesterol metabolism and hepatocellular carcinoma, and its important role in promoting hepatitis C virus (HCV) replication. This review will discuss the biogenesis and function of miR-122.Keywords
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