RANDOMIZED, CONTROLLED TRIAL EFFICACY OF PNEUMOCOCCAL CONJUGATE VACCINE AGAINST OTITIS MEDIA AMONG NAVAJO AND WHITE MOUNTAIN APACHE INFANTS
- 1 January 2008
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in The Pediatric Infectious Disease Journal
- Vol. 27 (1), 71-73
- https://doi.org/10.1097/inf.0b013e318159228f
Abstract
We report the phase III trial efficacy of 7-valent pneumococcal conjugate vaccine against clinical and culture proven otitis media (OM) among Navajo and White Mountain Apache infants. Efficacy was -0.4% (95% CI: -19.4 to 15.6) for clinically-diagnosed OM, 5.1% (95% CI: -51.5 to 40.6) for severe OM, and 64% (95% CI: -34% to 90%) for vaccine serotype pneumococcal OM suggesting that this vaccine is efficacious for pneumococcal OM in this high risk population.Keywords
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