A New Synthesis of Imidazolidin-2-ones via Pd-Catalyzed Carboamination of N-Allylureas
- 16 May 2006
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 8 (12), 2531-2534
- https://doi.org/10.1021/ol060707b
Abstract
A new strategy for the preparation of substituted imidazolidin-2-ones in two steps from readily available N-allylamines is described. Addition of the amine starting materials to isocyanates affords N-allylureas, which are converted to imidazolidin-2-one products with generation of two bonds and up to two stereocenters when treated with aryl bromides and catalytic amounts of Pd2(dba)3/Xantphos in the presence of NaOtBu.Keywords
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