Supercritical CO2 Extraction and Purification of Compounds with Antioxidant Activity
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- 8 March 2006
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 54 (7), 2441-2469
- https://doi.org/10.1021/jf052858j
Abstract
Supercritical fluid extraction (SCFE), based on the utilization of a fluid under supercritical conditions, is a technology suitable for extraction and purification of a variety of compounds, particularly those that have low volatility and/or are susceptible to thermal degradation. The interest in SCFE is promoted by legal limitations of conventional solvents for food and pharmaceutical uses. The physicochemical properties of supercritical CO2 (higher diffusivity, lower viscosity, and lower surface tension than conventional solvents) facilitate mass transfer and allow an environmentally friendly operation. This article presents a comprehensive compilation of data on the supercritical CO2 extraction of antioxidant compounds from vegetal materials, with particular attention to those of a phenolic nature. Aspects concerning the supercritical operation for extraction and fractionation of antioxidants compounds are considered, including equilibrium solubility of pure compounds and effects of the operational conditions on the antioxidant activity of isolated fractions. The data are compared to those reported for synthetic antioxidants and natural extracts obtained by conventional solvent extraction from vegetal matrices. Keywords: Activity; antioxidant; SCFEThis publication has 229 references indexed in Scilit:
- Determination of hydrogen peroxide scavenging activity of cinnamic and benzoic acids employing a highly sensitive peroxyoxalate chemiluminescence-based assay: Structure–activity relationshipsJournal of Pharmaceutical and Biomedical Analysis, 2005
- Phytochemical and antioxidant characterization of Hypericum perforatum alcoholic extractsFood Chemistry, 2005
- Standardized Methods for the Determination of Antioxidant Capacity and Phenolics in Foods and Dietary SupplementsJournal of Agricultural and Food Chemistry, 2005
- Hypoxia Inducible Factor Pathways as Targets for Functional FoodsJournal of Agricultural and Food Chemistry, 2005
- The Chemistry behind Antioxidant Capacity AssaysJournal of Agricultural and Food Chemistry, 2005
- Assays of physical stability and antioxidant activity of a topical formulation added with different plant extractsJournal of Pharmaceutical and Biomedical Analysis, 2005
- Interventions with antioxidants and nutrients in relation to oxidative DNA damage and repairMutation research. Reviews in mutation research, 2004
- Some applications of supercritical fluid extractionAnalytica Chimica Acta, 1988
- Über die antioxidative Aktivität von ZitrusfruchtschalenZeitschrift Fur Ernahrungswissenschaft, 1986
- Antioxidant activity of cashew-nut-shell liquid in black loaded natural rubber vulcanizatesPolymer, 1978