Relation of apparent diffusion coefficient with Ki-67 proliferation index in meningiomas
- 1 January 2016
- journal article
- Published by Oxford University Press (OUP) in The British Journal of Radiology
- Vol. 89 (1057), 20140842
- https://doi.org/10.1259/bjr.20140842
Abstract
The purpose of this study was to investigate the relationship between Ki-67 proliferation indexes and apparent diffusion coefficient (ADC) values of low-grade and atypical/anaplastic (high-grade) meningiomas. Pre-operative diffusion-weighted imaging and histopathological evaluation of 44 patients with meningiomas were performed retrospectively. Regions of interest (ROIs) were manually drawn on the ADC images. In total six ROI measurements were taken in three consecutive slices, and the average of the mean ADC value was used. The relationship between the ADC and Ki-67 values was investigated, and the ADC values of the low-grade and high-grade meningiomas were compared. 31 (70%) patients had low-grade the meningiomas. 10 (23%) patients had atypical and 3 (7%) had anaplastic meningiomas. ADC values of the low-grade and high-grade meningiomas were 0.81 ± 0.12 × 10−3 and 0.66 ± 0.08 × 10−3 mm2 s−1, respectively. Ki-67 proliferation indexes were 2.19% ± 1.14% for low-grade and 11.20% ± 9.80% for high-grade meningiomas. A statistically significant negative correlation between Ki-67 proliferation index and ADC values of the low-grade and high-grade meningiomas was detected (r2 = 0.326, p < 0.001). High-grade meningiomas had lower ADC values than that of low-grade meningiomas. There was statistically significant difference between the ADC values of the low-grade and high-grade meningiomas (p < 0.001). Our data provide an inverse correlation between the ADC and Ki-67 proliferation index values of meningiomas. ADC values can be used for histopathological characterization of the meningiomas and pre-surgical planning. The purpose of this study was to investigate the relationship between Ki-67 proliferation indexes and ADC values of low-grade and atypical/anaplastic (high-grade) meningiomas. In addition, we compared the ADC and Ki-67 proliferative index values of the low-grade and atypical/anaplastic (high-grade) meningiomas. We concluded that there was an inverse correlation between the ADC and Ki-67 proliferation index values in meningiomas, and we have found statistically significant difference between the ADC values of the low-grade and high-grade meningiomas. ADC values can be used for histopathological characterization of the meningiomas and pre-surgical planning.This publication has 22 references indexed in Scilit:
- Correlation of Apparent Diffusion Coefficient With Ki-67 Proliferation Index in Grading MeningiomaAmerican Journal of Roentgenology, 2014
- Preoperative histological grading of meningiomas using apparent diffusion coefficient at 3T MRIEuropean Journal of Radiology, 2013
- Histopathological classification and location of consecutively operated meningiomas at a single institution in China from 2001 to 2010.2013
- Diffusion-weighted MRI as a biomarker for treatment response in gliomaCNS Oncology, 2012
- CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2005-2009Neuro-Oncology, 2012
- Diffusion-weighted imaging does not predict histological grading in meningiomasActa Neurochirurgica, 2010
- WHO grade II and III meningiomas: a study of prognostic factorsJournal of Neuro-Oncology, 2009
- Diffusion-Weighted MR Imaging: Diagnosing Atypical or Malignant Meningiomas and Detecting Tumor DedifferentiationAmerican Journal of Neuroradiology, 2008
- The contribution of diffusion-weighted MR imaging to distinguishing typical from atypical meningiomasNeuroradiology, 2006
- Prognostic significance of Ki-67/MIB-1 proliferation index in meningiomas.2005