Effects of Thyroid Hormones on Serum Levels of Adipokines as Studied in Patients with Differentiated Thyroid Carcinoma During Thyroxine Withdrawal
- 1 April 2006
- journal article
- research article
- Published by Mary Ann Liebert Inc in Thyroid®
- Vol. 16 (4), 397-402
- https://doi.org/10.1089/thy.2006.16.397
Abstract
Objective: Previous studies addressing the influence of thyroid hormones on serum levels of adipokines yielded conflicting results. We aimed to study the impact of short-term overt hypothyroidism on serum leptin, resistin, and adiponectin levels in an in vivo human model. Design: Twenty-two women with differentiated thyroid carcinoma were studied the last day of their thyroxine-suppressive treatment, 4–7 days after withdrawal, and the day before whole-body scanning. Evaluations included serum thyroid hormone, leptin, resistin, and adiponectin concentrations, fasting glucose and insulin, lipid profiles, body temperature, body mass index, and total body fat mass. Main outcomes: Thyroid function changed from subclinical or mild hyperthyroidism to normal free thyroxine and triiodothyronine levels, ending in overt hypothyroidism. Thyroxine withdrawal resulted in an increase in serum resistin (p = 0.007) and leptin (p = 0.006) concentrations, whereas adiponectin levels remain unchanged. A significant decrease in body temperature during thyroxine withdrawal was paralleled by a decrease in fasting glucose (p = 0.006) and insulin resistance (p = 0.033), which occurred despite an increase in estimated total body fat mass. Conclusion: Thyroid hormones are important regulators of energy balance and intermediate metabolism, influencing the serum concentrations of leptin and resistin.Keywords
This publication has 24 references indexed in Scilit:
- Adiponectin and Adiponectin ReceptorsEndocrine Reviews, 2005
- Changes in adipocyte hormones leptin, resistin, and adiponectin in thyroid dysfunctionJournal of Cellular Biochemistry, 2004
- Comparison of the Release of Adipokines by Adipose Tissue, Adipose Tissue Matrix, and Adipocytes from Visceral and Subcutaneous Abdominal Adipose Tissues of Obese HumansEndocrinology, 2004
- The current biology of resistinJournal of Internal Medicine, 2004
- Serum concentrations of adipocytokines in patients with hyperthyroidism and hypothyroidism before and after control of thyroid functionClinical Endocrinology, 2003
- Circulating leptin and thyroid dysfunctionActa Endocrinologica, 2003
- Health CareAssociated Bloodstream InfectionsAnnals of Internal Medicine, 2003
- Resistin release by human adipose tissue explants in primary cultureBiochemical and Biophysical Research Communications, 2002
- Adipose Tissue as an Endocrine OrganTrends in Endocrinology & Metabolism, 2000
- What's in a Name? In Search of Leptin's Physiologic RoleJournal of Clinical Endocrinology & Metabolism, 1998