Differentially Evolved Genes of Salmonella Pathogenicity Islands: Insights into the Mechanism of Host Specificity in Salmonella
Open Access
- 3 December 2008
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 3 (12), e3829
- https://doi.org/10.1371/journal.pone.0003829
Abstract
The species Salmonella enterica (S. enterica) includes many serovars that cause disease in avian and mammalian hosts. These serovars differ greatly in their host range and their degree of host adaptation. The host specificity of S. enterica serovars appears to be a complex phenomenon governed by multiple factors acting at different stages of the infection process, which makes identification of the cause/s of host specificity solely by experimental methods difficult. In this study, we have employed a molecular evolution and phylogenetics based approach to identify genes that might play important roles in conferring host specificity to different serovars of S. enterica. These genes are ‘differentially evolved’ in different S. enterica serovars. This list of ‘differentially evolved’ genes includes genes that encode translocon proteins (SipD, SseC and SseD) of both Salmonella pathogenicity islands 1 and 2 encoded type three secretion systems, sptP, which encodes an effector protein that inhibits the mitogen-activated protein kinase pathway of the host cell, and genes which encode effector proteins (SseF and SifA) that are important in placing the Salmonella-containing vacuole in a juxtanuclear position. Analysis of known functions of these ‘differentially evolved genes’ indicates that the products of these genes directly interact with the host cell and manipulate its functions and thereby confer host specificity, at least in part, to different serovars of S. enterica that are considered in this study.This publication has 54 references indexed in Scilit:
- Clustal W and Clustal X version 2.0Bioinformatics, 2007
- Salmonella Pathogenicity Island 4 encodes a giant non-fimbrial adhesin and the cognate type 1 secretion systemCellular Microbiology, 2007
- The Translocated Salmonella Effector Proteins SseF and SseG Interact and Are Required To Establish an Intracellular Replication NicheInfection and Immunity, 2006
- The type III secretion injectisomeNature Reviews Microbiology, 2006
- IpaD Localizes to the Tip of the Type III Secretion System Needle of Shigella flexneriInfection and Immunity, 2006
- Genetic Determinants and Polymorphisms Specific for Human-Adapted Serovars of Salmonella enterica That Cause Enteric FeverJournal of Clinical Microbiology, 2006
- Genome-Wide Screen for Salmonella Genes Required for Long-Term Systemic Infection of the MousePLoS Pathogens, 2006
- DnaSP, DNA polymorphism analyses by the coalescent and other methodsBioinformatics, 2003
- Multiple Comparisons of Log-Likelihoods with Applications to Phylogenetic InferenceMolecular Biology and Evolution, 1999
- Basic local alignment search toolJournal of Molecular Biology, 1990