Arg74 in HLA-DRBI and DRB3 controls a DR3-related epitope
- 1 January 1990
- journal article
- Published by Springer Science and Business Media LLC in Immunogenetics
- Vol. 32 (1), 8-12
- https://doi.org/10.1007/bf01787322
Abstract
TR81 is a specificity closely related to or identical with DR3. In Caucasoids two amino acids, Tyr at position 26 and Arg at position 74 of HLA class II DRβ chains, have been found to be associated with the presence of TR81. Recently, a variant of DRBI *03 identified in American Blacks has been shown to possess Arg at position 74 but Phe at position 26. This codon combination is found to be present in four other cell lines where it still specifies the TR81 determinant. This suggests that the TR81 specificity is uniquely dependent on the presence of Arg at position 74.Keywords
This publication has 22 references indexed in Scilit:
- DNA sequence analysis of the HLA-DRw12 alleleHuman Immunology, 1989
- The DR3(w18),DQw4 haplotype differs from DR3(w17),DQw2 haplotypes at multiple class II lociHuman Immunology, 1989
- First domain sequence of the HLA-DRB1 chain from two HLA-DRw14 homozygous typing cell lines: TEM (Dw9) and AMALA (Dw16)Human Immunology, 1989
- DNA typing of DRw6 subtypes: Correlation with DRB1 and DRB3 allelic sequences by hybridization with oligonucleotide probesHuman Immunology, 1989
- A hypothetical model of the foreign antigen binding site of Class II histocompatibility moleculesNature, 1988
- HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitusNature, 1987
- Polymorphism of human Ia antigens: gene conversion between two DR β loci results in a new HLA-D/DR specificityNature, 1986
- Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell AnemiaScience, 1985
- Assessment of the specificity of human Iaalloantisera and alloantigens by the use of radioiodinated human Ia antigensTissue Antigens, 1982
- HLA-DR TYPING BY RADIOIMMUNOASSAYTransplantation, 1980