Functional Dissociation within the Entorhinal Cortex for Memory Retrieval of an Association between Temporally Discontiguous Stimuli
Open Access
- 18 April 2012
- journal article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 32 (16), 5356-5361
- https://doi.org/10.1523/jneurosci.5227-11.2012
Abstract
Anatomical connectivity and single neuron coding suggest a segregation of information representation within lateral (LEC) and medial (MEC) portions of the entorhinal cortex, a brain region serving as the primary input/output of the hippocampus and maintaining widespread connections to many association cortices. The present study aimed to expand this idea by examining whether these two subregions differentially contribute to memory retrieval for an association between temporally discontiguous stimuli. We found that reversible inactivation of the LEC, but not the MEC, severely impaired the retrieval of the recently and remotely acquired memory in rat trace eyeblink conditioning, in which a stimulus-free interval was interposed between the conditioned and unconditioned stimulus. Conversely, inactivation of the LEC had no effect on retrieval in delay eyeblink conditioning, where two stimuli were presented without an interval. Therefore, the LEC, but not the MEC, plays a long-lasting role in the retrieval of a memory for an association between temporally discontiguous stimuli.This publication has 37 references indexed in Scilit:
- Temporary inactivation of the dorsal entorhinal cortex impairs acquisition and retrieval of spatial informationNeurobiology of Learning and Memory, 2010
- Cortical efferents of the perirhinal, postrhinal, and entorhinal cortices of the ratHippocampus, 2009
- mGluR‐dependent persistent firing in entorhinal cortex layer III neuronsEuropean Journal of Neuroscience, 2008
- Imaging the spread of reversible brain inactivations using fluorescent muscimolJournal of Neuroscience Methods, 2008
- What Does the Anatomical Organization of the Entorhinal Cortex Tell Us?Neural Plasticity, 2008
- The Fate of Old Memories after Medial Temporal Lobe DamageJournal of Neuroscience, 2006
- Mechanisms underlying working memory for novel informationTrends in Cognitive Sciences, 2006
- Microstructure of a spatial map in the entorhinal cortexNature, 2005
- Involvement of entorhinal cortex or parietal cortex in long-term spatial discrimination memory in rats: Retrograde amnesia.Behavioral Neuroscience, 1996
- LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONSJournal of Neurology, Neurosurgery & Psychiatry, 1957