An immunohistochemical study of bizarre neoplastic cells in pleomorphic adenoma: Its cytological nature and proliferative activity
- 1 November 1999
- journal article
- research article
- Published by Wiley in Pathology International
- Vol. 49 (11), 993-999
- https://doi.org/10.1046/j.1440-1827.1999.00968.x
Abstract
The cytological nature and proliferative activity of bizarre neoplastic cells, widely scattered in pleomorphic adenomas of salivary gland origin were studied. Pleomorphic adenomas containing numerous bizarre neoplastic cells were found in four cases, and were equal to 2.9% of all pleomorphic adenomas examined. All four cases presented as well‐circumscribed, firm masses measuring less than 1.5 cm in size, located in the palate, and were of 7 months to 4 years duration. Histopathologically, these pleomorphic adenomas were cell rich type, and were well demarcated from surrounding tissues, although their fibrous capsules were partially defective. In addition to characteristic histopathological findings of pleomorphic adenoma, numerous neoplastic cells with bizarre appearance were scattered throughout the lesion, excepting for tubuloductal structures. These bizarre neoplastic cells had irregular‐shaped and large nuclei with or without hyperchromatism, although their nucleoli were small and mitotic figures were few. Furthermore, there were many multinucleated giant cells, some of which showed multilobulated nuclei. Neither necrosis nor infarct was seen in the tumors. Immunohistochemically, bizarre neoplastic cells scattered in solid‐proliferating areas and myxoid areas were neoplastic myoepithelial cells in nature. There was no statistical significance of MIB‐1 labeling indices between pleomorphic adenomas with bizarre neoplastic cells and usual pleomorphic adenomas. The p53 labeling indices were quite low. Although the benign nature of pleomorphic adenomas with numerous bizarre neoplastic cells and hypercellularity, distinguishing such pleomorphic adenomas from various stages of malignant transformation in pleomorphic adenomas and other carcinomas should be made by histological section of submitted biopsy specimen or aspirated content for cytological diagnosis. The present paper suggests that the term ‘bizarre cell pleomorphic adenoma’ is an appropriate name for this neoplasm, in that it is distinguished from the usual benign pleomorphic adenoma which is easily diagnosed by routinely prepared histological or cytological stainings.Keywords
This publication has 21 references indexed in Scilit:
- Assessment of Proliferative Activity Using the MIB1 Antibody Helps to Distinguish Polymorphous Low Grade Adenocarcinoma from Adenoid Cystic Carcinoma of Salivary GlandsPathology - Research and Practice, 1997
- Role of p53 Immunohistochemistry in Differentiating Reactive Gliosis From Malignant Astrocytic LesionsThe American Journal of Surgical Pathology, 1996
- Coexpression of p53 and c-erbB-2 proteins is associated with histological type, tumour stage, and cell proliferation in malignant salivary gland tumoursVirchows Archiv, 1996
- Epithelial cell proliferation in odontogenic keratocysts: a comparative immunocytochemical study of Ki67 in simple, recurrent and basal cell naevus syndrome (BCNS)‐associated lesionsJournal of Oral Pathology & Medicine, 1995
- Cell proliferation correlates with prognosis in acinic cell carcinomas of salivary gland origin. Immunohistochemical study of 30 cases using the MIB 1 antibody in formalin‐fixed paraffin sectionsThe Journal of Pathology, 1994
- Monoclonal antibodies against recombinant parts of the Ki‐67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave‐processed formalin‐fixed paraffin sectionsThe Journal of Pathology, 1992
- Monoclonal antibody Ki‐67: its use in histopathologyHistopathology, 1990
- Tumors of the intraoral minor salivary glands: A demographic and histologic study of 426 casesOral Surgery, Oral Medicine, Oral Pathology, 1988
- Salivary neoplasms: Overview of a 35‐year experience with 2,807 patientsHead & Neck Surgery, 1986
- Salivary gland tumours. A review of 2410 cases with particular reference to histological types, site, age and sex distributionThe Journal of Pathology, 1985