Association between Sarcopenia, Bone Density, and Health-Related Quality of Life in Korean Men
Open Access
- 1 January 2013
- journal article
- Published by The Korean Academy of Family Medicine in Korean Journal of Family Medicine
- Vol. 34 (4), 281-288
- https://doi.org/10.4082/kjfm.2013.34.4.281
Abstract
Sarcopenia is the loss of muscle mass leading to decreased muscle strength, physical disability, and increased mortality. The genesis of both sarcopenia and osteoporosis is multifactorial, and several factors that play a role in osteoporosis are thought to contribute to sarcopenia. This study evaluated the association between sarcopenia and bone density and health-related quality of life in Korean men. We used the data of 1,397 men over 50 years of age from the 2009 Korean National Health and Nutrition Examination Survey. Sarcopenia was defined as the appendicular skeletal muscle mass divided by height(2) (kg/m(2)) < 2 standard deviations below the sex-specific mean for young adults. Health-related quality of life was measured by the EuroQol-5 dimension (EQ-5D) instrument. Logistic regression analysis was performed to evaluate the relationship between sarcopenia, bone density, and health-related quality of life. The T-score of the lumbar spine, total femur, and femur neck in bone mineral density in subjects with sarcopenia were lower than those in subjects without sarcopenia. The score of the EQ-5D index was significantly lower and the rate of having problems with individual components of health-related quality of life was higher in the sarcopenic group. After adjustment for age and body mass index, the odds ratios (ORs) (95% confidence interval [CI]) for sarcopenia were 2.06 (1.07-3.96) in osteopenic subjects and 3.49 (1.52-8.02) in osteoporotic subjects, respectively. After adjustment, the total score of the EQ-5D index was significantly lower in the sarcopenic subjects. The ORs (95% CI) for having problems of mobility and usual activity of the EQ-5D descriptive system were 1.70 (1.02-2.84) and 1.90 (1.09-3.31), respectively. Sarcopenia was associated with decreased bone mineral density in Korean men. In addition, sarcopenia was related to poor quality of life, especially with regard to mobility and usual activity. Greater attention to and evaluation for sarcopenia are needed in subjects showing low bone mineral density to prevent and manage poor quality of life.Keywords
This publication has 40 references indexed in Scilit:
- Prevalence and trends in low femur bone density among older US adults: NHANES 2005–2006 compared with NHANES IIIJournal of Bone and Mineral Research, 2020
- Sarcopenia and Age-Related Endocrine FunctionInternational Journal of Endocrinology, 2012
- Prevalence of sarcopenia and its association with osteoporosis in 313 older women following a hip fractureArchives of Gerontology and Geriatrics, 2011
- Resistance exercise for muscular strength in older adults: A meta-analysisAgeing Research Reviews, 2010
- Correlation between manual muscle strength and interleukin-6 (IL-6) plasma levels in elderly community-dwelling womenArchives of Gerontology and Geriatrics, 2009
- Alterations in Muscle Attenuation following Detraining and Retraining in Resistance-Trained Older AdultsGerontology, 2008
- European guidance for the diagnosis and management of osteoporosis in postmenopausal womenOsteoporosis International, 2008
- Relationship Between Low Levels of Anabolic Hormones and 6-Year Mortality in Older MenThe Aging in the Chianti Area (InCHIANTI) StudyArchives of Internal Medicine, 2007
- Skeletal Muscle Ribonuclease Activities in Chronically Ethanol‐Treated RatsAlcohol: Clinical and Experimental Research, 1998
- EuroQol - a new facility for the measurement of health-related quality of lifeHealth Policy, 1990