Organization of the human serotonin transporter gene
- 1 June 1994
- journal article
- Published by Springer Science and Business Media LLC in Journal of Neural Transmission
- Vol. 95 (2), 157-162
- https://doi.org/10.1007/bf01276434
Abstract
The gene encoding the human serotonin transporter (5-HTT) has been isolated and characterized. The human 5-HTT gene is composed of 14 exons spanning ∼ 31 kb. The sequence of all exons including adjacent intronic sequences and a tandem repeat DNA polymorphism (VNTR) has been determined and deposited in the EMBL/GenBank data base with the accession numbers X76753 to X76762. The characterization of 5-HTT gene will aid to advance molecular pharmacologic studies of 5-HT uptake regulation and facilitate investigations of its role in psychiatric disorders.Keywords
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