Rethinking the causes of pain in herpes zoster and postherpetic neuralgia: the ectopic pacemaker hypothesis
Open Access
- 1 November 2018
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Pain Reports
- Vol. 3 (6), e702
- https://doi.org/10.1097/PR9.0000000000000702
Abstract
Introduction: Pain in herpes zoster (HZ) and postherpetic neuralgia (PHN) is traditionally explained in terms of 2 processes: irritable nociceptors in the rash-inflamed skin and, later, deafferentation due to destruction of sensory neurons in one virally infected dorsal root ganglion. Objectives and methods: Consideration of the evidence supporting this explanation in light of contemporary understanding of the pain system finds it wanting. An alternative hypothesis is proposed as a replacement. Results: This model, the ectopic pacemaker hypothesis of HZ and PHN, proposes that pain in both conditions is driven by hyperexcitable ectopic pacemaker sites at various locations in primary sensory neurons affected by the causative varicella zoster virus infection. This peripheral input is exacerbated by central sensitization induced and maintained by the ectopic activity. Conclusions: The shift in perspective regarding the pain mechanism in HZ/PHN has specific implications for clinical management.Keywords
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