Immune-endocrine interactions and Leydig cell function: the role of cytokines
- 31 January 2003
- journal article
- review article
- Published by Hindawi Limited in Andrologia
- Vol. 35 (1), 55-63
- https://doi.org/10.1046/j.1439-0272.2003.00537.x
Abstract
Inflammatory disease is known to affect male reproductive function and fertility. Male accessory gland infections (MAGI) account for almost 15% of all cases of male infertility seen in infertility clinics. Infections of the male accessory glands are associated with increased counts of white blood cells in semen and elevated levels of pro‐inflammatory cytokines in the semen and the testis. Numerous studies have underscored the importance of cytokines in the regulation of testicular and glandular function during pathophysiological events as well as under normal physiological conditions when cytokines act as growth and differentiation factors. The purpose of this paper is to particularly review the role of cytokines in the regulation of Leydig cell function in the testis primarily under pathophysiological conditions, and also considers clinical investigations that help to improve the evaluation and treatment of male infertility.Keywords
This publication has 56 references indexed in Scilit:
- Effect of human and murine interferon-α on steroid production by rat ovarian cellsLife Sciences, 1998
- The effect of tumor necrosis factor-α and cAMP on induction of AP-1 activity in MA-10 tumor leydig cellsEndocrine, 1997
- Reproductive effects of chronic administration of murine interferon-gammaReproductive Toxicology, 1996
- Leukocyte Populations of the Adult Rat Testis Following Removal of the Leydig Cells by Treatment With Ethane Dimethane Sulfonate and Subcutaneous Testosterone Implants1Biology of Reproduction, 1994
- Vasopressin biosynthesis in rodent Leydig cellsMolecular and Cellular Endocrinology, 1992
- Interferons: Pleiotropic cellular modulatorsClinical Immunology and Immunopathology, 1992
- Inflammatory cytokinesClinical Immunology and Immunopathology, 1992
- Letter to the editorInternational Journal of Cancer, 1986
- Human leukocyte interferon inhibits human chorionic gonadotropin stimulated testosterone production by porcine leydig cells in cultureBiochemical and Biophysical Research Communications, 1985
- Diagnosis of Accessory Gland Infection and its Possible Role in Male InfertilityInternational Journal of Andrology, 1980