Cytomegalovirus Retinitis in an ALL Child on Exclusive Chemotherapy Treated Successfully With Intravitreal Ganciclovir Alone
- 1 April 2013
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Pediatric Hematology/Oncology
- Vol. 35 (3), e118-e119
- https://doi.org/10.1097/mph.0b013e31827078ad
Abstract
A child suffering from acute lymphoblastic leukemia on treatment with exclusive chemotherapy presented with vision-threatening cytomegalovirus (CMV) retinitis in 1 eye. Prompt diagnosis and treatment with 3 weekly doses of 2 mg/0.1 mL intravitreal ganciclovir resulted in successful healing of CMV retinitis with restoration of visual acuity. In children with acute lymphoblastic leukemia on exclusive chemotherapy without hematopoietic stem cell transplantation, CMV retinitis has been reported in only 1 case in literature. This child was treated successfully with intravenous ganciclovir. This report highlights the use of successful intravitreal ganciclovir in pediatric age group to avoid side effects of systemic ganciclovir.Keywords
This publication has 7 references indexed in Scilit:
- Rationale for an international consortium to study inherited genetic susceptibility to childhood acute lymphoblastic leukemiaHaematologica, 2011
- Benefit of dexamethasone compared with prednisolone for childhood acute lymphoblastic leukaemia: results of the UK Medical Research Council ALL97 randomized trialBritish Journal of Haematology, 2005
- Clinical characteristics and outcomes of cytomegalovirus retinitis in persons without human immunodeficiency virus infectionAmerican Journal of Ophthalmology, 2004
- Intravitreal sustained-release ganciclovir implants for severe bilateral cytomegalovirus retinitis after stem cell transplantationActa Ophthalmologica Scandinavica, 2002
- Cytomegalovirus retinitis in immunosuppressed childrenAmerican Journal of Ophthalmology, 1999
- High-dose (2000-μg) intravitreous ganciclovir in the treatment of cytomegalovirus retinitisOphthalmology, 1998
- Incidence and prognosis of cytomegalovirus infections following allogenic bone marrow transplantationJournal of Medical Virology, 1987