Endometriosis: The Role of Neuroangiogenesis
- 17 March 2011
- journal article
- review article
- Published by Annual Reviews in Annual Review of Physiology
- Vol. 73 (1), 163-182
- https://doi.org/10.1146/annurev-physiol-012110-142158
Abstract
Endometriosis is a common cause of pelvic pain and infertility, affecting ∼10% of reproductive-age women. Annual costs for medical and surgical care in the United States exceed $20 billion. The disorder is characterized by implants of endometrial tissue outside the uterine cavity. Endometriotic lesions induce a state of chronic peritoneal inflammation, accompanied by elevated prostaglandin, cytokine, and growth factor concentrations. The current therapy is surgical ablation of ectopic implants and hormones that block the hypothalamic-pituitary-ovarian axis, but these approaches are expensive, carry perioperative risks, or have unpleasant side effects of hypoestrogenism. Recent evidence indicates that ectopic endometriotic implants recruit their own unique neural and vascular supplies through neuroangiogenesis. It is believed that these nascent nerve fibers in endometriosis implants influence dorsal root neurons within the central nervous system, increasing pain perception in patients. We consider the mechanisms and therapeutic implications of neuroangiogenesis in these lesions and propose potential treatments for the control or elimination of endometriosis-associated pain.Keywords
This publication has 98 references indexed in Scilit:
- Ovarian cancer in endometriosis: molecular biology, pathology, and clinical managementInternational Journal of Clinical Oncology, 2009
- Endometriosis-induced vaginal hyperalgesia in the rat: Effect of estropause, ovariectomy, and estradiol replacementPain, 2007
- PPAR-gamma receptor ligand induces regression of endometrial explants in baboons: A prospective, randomized, placebo- and drug-controlled studyFertility and Sterility, 2007
- Efficacy of levamisole on experimental endometriosisInternational Journal of Gynecology & Obstetrics, 2007
- Detection of peritoneal endometriotic lesions by autofluorescence laparoscopyAmerican Journal of Obstetrics and Gynecology, 2006
- Reproductive History and Endometriosis Among Premenopausal WomenObstetrics & Gynecology, 2004
- Proteinase-activated receptors: novel signals for peripheral nervesTrends in Neurosciences, 2003
- Epithelial neutrophil-activating peptide 78 concentrations are elevated in the peritoneal fluid of women with endometriosisFertility and Sterility, 2003
- Fluorescence and photosensitization of experimental endometriosis in the rat after systemic 5-aminolevulinic acid administration: A potential new approach to the diagnosis and treatment of endometriosisAmerican Journal of Obstetrics and Gynecology, 1996
- Endometriosis, 1995 - confusion or sense?International Journal of Gynecology & Obstetrics, 1995