Smoking Cessation and the Risk of Diabetes Mellitus and Impaired Fasting Glucose: Three-Year Outcomes after a Quit Attempt
Open Access
- 3 June 2014
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 9 (6), e98278
- https://doi.org/10.1371/journal.pone.0098278
Abstract
Weight gain after smoking cessation may increase diabetes mellitus and impaired fasting glucose (IFG) risk. This study evaluated associations between smoking cessation and continued smoking with incident diabetes and IFG three years after a quit attempt. The 1504 smokers (58% female) were mean (standard deviation) 44.7 (11.1) years old and smoked 21.4 (8.9) cigarettes/day. Of 914 participants with year 3 data, the 238 abstainers had greater weight gain, increase in waist circumference, and increase in fasting glucose levels than the 676 continuing smokers (p≤0.008). In univariate analyses, Year 3 abstinence was associated with incident diabetes (OR = 2.60, 95% CI 1.44–4.67, p = .002; 4.3% absolute excess) and IFG (OR = 2.43, 95% CI 1.74–3.41, p<0.0001; 15.6% absolute excess). In multivariate analyses, incident diabetes was associated independently with older age (p = 0.0002), higher baseline body weight (p = 0.021), weight gain (p = 0.023), baseline smoking rate (p = 0.008), baseline IFG (p<0.0001), and baseline hemoglobin A1C (all p<0.0001). Smoking more at baseline predicted incident diabetes among eventual abstainers (p<0.0001); weighing more at baseline predicted incident diabetes among continuing smokers (p = 0.0004). Quitting smoking is associated with increased diabetes and IFG risk. Independent risk factors include older age, baseline body weight, baseline glycemic status, and heavier pre-quit smoking. These findings may help target smokers for interventions to prevent dysglycemia. Clinicaltrials.gov NCT00332644Keywords
This publication has 42 references indexed in Scilit:
- Weight gain in smokers after quitting cigarettes: meta-analysisBMJ, 2012
- Effects of smoking and smoking cessation on lipids and lipoproteins: Outcomes from a randomized clinical trialAmerican Heart Journal, 2010
- New Methods for Tobacco Dependence Treatment ResearchAnnals of Behavioral Medicine, 2010
- Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European AmericansGenes, Brain and Behavior, 2010
- Effects of Smoking and Smoking Cessation on Endothelial FunctionJournal of the American College of Cardiology, 2010
- 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes StudyThe Lancet, 2009
- A Randomized Placebo-Controlled Clinical Trial of 5 Smoking Cessation PharmacotherapiesArchives of General Psychiatry, 2009
- Deciphering the Impact of Common Genetic Variation on Lung Cancer Risk: A Genome-Wide Association StudyCancer Research, 2009
- A Candidate Gene Approach Identifies the CHRNA5-A3-B4 Region as a Risk Factor for Age-Dependent Nicotine AddictionPLoS Genetics, 2008
- Smoking and smoking cessation—The relationship between cardiovascular disease and lipoprotein metabolism: A reviewAtherosclerosis, 2008