Immune functions encoded by the natural killer gene complex
- 1 April 2003
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Immunology
- Vol. 3 (4), 304-316
- https://doi.org/10.1038/nri1055
Abstract
There has been marked progress in our understanding of the role of natural killer (NK) cells in immune responses, mainly due to the identification of NK-cell receptors and their ligands. The genes encoding many NK-cell receptors are located in the NK-gene complex (NKC). Here, we review the properties of NKC-encoded receptors, and provide a genomic and conceptual framework for an insight into NK-cell function and biology.Keywords
This publication has 102 references indexed in Scilit:
- Viral evasion of natural killer cellsNature Immunology, 2002
- Dectin-1 Is A Major β-Glucan Receptor On MacrophagesThe Journal of Experimental Medicine, 2002
- Ly49i2 is an inhibitory rat natural killer cell receptor for an MHC class Ia molecule (RT1-A1c)European Journal of Immunology, 2002
- Human NK-cell receptorsImmunology Today, 2000
- A family of inhibitory and activating Ig-like receptors that modulate function of lymphoid and myeloid cellsSeminars in Immunology, 2000
- NK cell recognition of non-classical HLA class I moleculesSeminars in Immunology, 2000
- Peptide dependency and selectivity of the NK cell inhibitory receptor Ly-49CEuropean Journal of Immunology, 1999
- Cloning of NKG2‐F, a new member of the NKG2 family of human natural killer cell receptor genesEuropean Journal of Immunology, 1997
- A 2-Mb YAC Contig and Physical Map of the Natural Killer Gene Complex on Mouse Chromosome 6Genomics, 1997
- NKR-P1, a Signal Transduction Molecule on Natural Killer CellsScience, 1990