The role of centrosomes in mammalian fertilization and its significance for ICSI
Open Access
- 23 June 2009
- journal article
- review article
- Published by Oxford University Press (OUP) in Molecular Human Reproduction
- Vol. 15 (9), 531-538
- https://doi.org/10.1093/molehr/gap049
Abstract
Centrosome integrity is critically important for successful fertilization and embryo development. In humans, the sperm contributes the dominant centrosomal material containing centrioles and centrosomal components onto which oocyte centrosomal proteins assemble after sperm incorporation to form the sperm aster that is essential for uniting sperm and oocyte pronuclei. Increasingly, dysfunctional sperm centrosomes have been identified as a factor for sperm-derived infertility and heterologous Intracytoplasmic Sperm Injection (ICSI) has been used to assess centrosome and sperm aster formation and clearly established a relationship between infertility and sperm centrosomal dysfunction. ICSI has been used successfully to provide novel treatment to overcome male factor infertility and it may open up new possibilities to correct specific sperm-related centrosome dysfunctions at molecular levels. New data indicate that it is now possible to replace dysfunctional centrosomes with functional donor sperm centrosomes which may provide new treatment for couples in which infertility is a result of centrosome-related sperm dysfunctions.Keywords
This publication has 61 references indexed in Scilit:
- The mammalian centrosome and its functional significanceHistochemistry and Cell Biology, 2008
- Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signalingNature Genetics, 2007
- Poor Centrosomal Function of Cat Testicular Spermatozoa Impairs Embryo Development In Vitro after Intracytoplasmic Sperm Injection1Biology of Reproduction, 2006
- Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assemblyThe Journal of cell biology, 2004
- Proteomic characterization of the human centrosome by protein correlation profilingNature, 2003
- Phosphorylation of Centrin during the Cell Cycle and Its Role in Centriole Separation Preceding Centrosome DuplicationPublished by Elsevier BV ,2001
- Pericentrin and γ-Tubulin Form a Protein Complex and Are Organized into a Novel Lattice at the CentrosomeThe Journal of cell biology, 1998
- Centrin is a conserved protein that forms diverse associations with centrioles and MTOCs inNaegleria and other organismsCell Motility, 1996
- De novo formation of centrioles in parthenogenetically activated, diploidized rabbit embryosBiology of the Cell, 1991
- The fine structure and development of the neck region of the mammalian spermatozoonThe Anatomical Record, 1969