Molecular Genetics of Late‐Onset Alzheimer's Disease
- 28 June 2004
- journal article
- review article
- Published by Wiley in Annals of Human Genetics
- Vol. 68 (4), 381-404
- https://doi.org/10.1046/j.1529-8817.2004.00110.x
Abstract
Late-onset Alzheimer's disease (AD) is a complex and multifactorial disease with the possible involvement of several genes. Apolipoprotein E (APOE), especially the APOE*4 allele, has been established as a strong susceptibility marker that accounts for nearly 30% of the risk in late-onset AD. However, as the APOE*4 allele is neither necessary nor sufficient for the development of AD, it emphasizes the involvement of other genetic and/or environmental factors which, alone or in conjunction with APOE*4, can modify the risk of AD. Recently, genome-wide linkage or linkage disequilibrium studies on late-onset AD have provided informative data for the existence of multiple putative genes for AD on several chromosomes, with the strongest evidence on chromosomes 12, 10, 9 and 6. This paper attempts to review the current progress on the identification of additional genetic loci for late-onset AD.Keywords
This publication has 130 references indexed in Scilit:
- Genetic variants in a haplotype block spanningIDE are significantly associated with plasma A?42 levels and risk for Alzheimer diseaseHuman Mutation, 2004
- How heritable is Alzheimer's disease late in life? Findings from Swedish twinsAnnals of Neurology, 2003
- Genetic variation in a haplotype block spanningIDE influences Alzheimer diseaseHuman Mutation, 2003
- Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulinHuman Molecular Genetics, 2003
- Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE)Neuroscience Letters, 2003
- The Amyloid Precursor Protein Locus and Very-Late-Onset Alzheimer DiseaseAmerican Journal of Human Genetics, 2001
- Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implicationsProceedings of the National Academy of Sciences of the United States of America, 2001
- Exploring the new world of the genome with DNA microarraysNature Genetics, 1999
- LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradationCell, 1995
- Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's diseaseNature, 1991