Gender Differences in the Relationship Between Periodontal Disease, Tooth Loss, and Atherosclerosis
- 1 September 2004
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 35 (9), 2029-2035
- https://doi.org/10.1161/01.str.0000136767.71518.36
Abstract
Background and Purpose— Males carry a disproportionate burden of cardiovascular disease. Because males also bear a higher burden of periodontal disease, we investigated the existence of gender differences in the postulated relationship between periodontal infections, tooth loss, and subclinical atherosclerosis. Methods— A total of 1710 randomly enrolled participants between the ages of 45 and 75 with no history of myocardial infarction or stroke received a clinical periodontal examination, carotid scan using high-resolution B-mode ultrasound, and extensive measurements for conventional cardiovascular risk factors (age, education, smoking, alcohol, body mass index, diabetes, systolic blood pressure, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, and triglycerides) as well as markers of healthy lifestyle and social network. Results— In both genders, measures of current and long-term periodontitis worsened as tooth loss increased. In males but not females, an ≈10% difference in carotid artery plaque prevalence was observed between the lowest and highest tertiles of tooth loss ( P P =0.05) after multivariate adjustment. Similar patterns were observed for intima–media thickness. The influence of gender on carotid artery plaque prevalence was most evident among the younger age group (Conclusions— Our data suggest that tooth loss and long-term periodontitis are related to subclinical atherosclerosis in men but not women. Gender variations in cardiovascular morbidity or mortality may be explained partly by the differential contributions of novel risk factors across genders.Keywords
This publication has 9 references indexed in Scilit:
- Periodontal Disease as a Risk Factor for Ischemic StrokeStroke, 2004
- Relationship Between Periodontal Disease, Tooth Loss, and Carotid Artery PlaqueStroke, 2003
- The Applicability of Half-Mouth Examination to Periodontal Disease Assessment in Untreated Adult PopulationsThe Journal of Periodontology, 2002
- Periodontal attachment level of extractions presumably performed for periodontal reasonsJournal of Clinical Periodontology, 2002
- Study of Health in Pomerania (SHIP): A health examination survey in an east German region: Objectives and designInternational Journal of Public Health, 2001
- Relationship between bone mineral density and tooth loss in elderly Japanese womenDento maxillo facial radiology, 1999
- Misclassification of Smoking in a Follow-up Population Study in Southern GermanyJournal of Clinical Epidemiology, 1998
- Systemic acute-phase reactants, C-reactive protein and haptoglobin, in adult periodontitisClinical and Experimental Immunology, 1997
- Compendium of Physical Activities: classification of energy costs of human physical activitiesMedicine & Science in Sports & Exercise, 1993