The effects of vitamin D repletion on endothelial function and inflammation in patients with coronary artery disease
Open Access
- 26 November 2012
- journal article
- research article
- Published by SAGE Publications in Vascular Medicine
- Vol. 17 (6), 394-404
- https://doi.org/10.1177/1358863x12466709
Abstract
Adequate vitamin D levels may promote cardiovascular health by improving endothelial function and down-regulating inflammation. The objective of this pilot trial was to investigate the effects of vitamin D repletion on endothelial function and inflammation in patients with coronary artery disease (CAD). Using a double-blind placebo wait-list control design, 90 subjects with CAD and vitamin D deficiency (< 20 ng/ml) were randomized 1:1 to 50,000 IU of oral ergocalciferol or placebo weekly for 12 weeks. Endothelial function (reactive hyperemia peripheral arterial tonometry, RH-PAT), circulating adhesion molecules, and pro-inflammatory cytokines were measured at baseline and 12 weeks. The median increase in serum 25-vitamin D from baseline was 26 ± 17 ng/ml in the active group and 4 ± 8 ng/ml in the placebo group (between-group difference = 22 ng/ml, p < 0.001). The median within-subject change in RH-PAT score was 0.13 ± 0.73 with active treatment and −0.04 ± 0.63 with placebo (between-group difference = 0.17, p = 0.44). Within-group and between-group differences in intercellular adhesion molecule levels were greater with placebo (between-group difference = 6 ng/ml, p = 0.048). Vascular cell adhesion molecule levels decreased in both groups by a similar magnitude (median difference between groups = 8.5 ng/ml, p = 0.79). There was no difference between groups in magnitude of reduction in interleukin (IL)-12 (−8.6 ng/ml, p = 0.72) and interferon-gamma (0.52 ng/ml, p = 0.88). No significant differences in blood pressure, e-selectin, high-sensitivity c-reactive protein, IL-6 or the chemokine CXCL-10 were found with treatment. In conclusion, repleting vitamin D levels in subjects with CAD failed to demonstrate any benefits on surrogate markers of cardiovascular health. These results question the role of vitamin D supplementation in modifying cardiovascular disease.Keywords
This publication has 39 references indexed in Scilit:
- Vitamin D, obesity, and obesity-related chronic disease among ethnic minorities: A systematic reviewNutrition, 2011
- Vitamin D and Cardiovascular Disease: Time for Large Randomized TrialsJournal of the American College of Cardiology, 2011
- Vitamin D and Cardiovascular DiseaseJournal of the American College of Cardiology, 2011
- Vitamin D, Parathyroid Hormone, and Cardiovascular Events Among Older AdultsJournal of the American College of Cardiology, 2011
- Vitamin D Status and the Risk of Cardiovascular Disease DeathAmerican Journal of Epidemiology, 2009
- Demographic Differences and Trends of Vitamin D Insufficiency in the US Population, 1988-2004Archives of Internal Medicine, 2009
- Vitamin D DeficiencyJournal of the American College of Cardiology, 2008
- Independent Association of Low Serum 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels With All-Cause and Cardiovascular MortalityArchives of Internal Medicine, 2008
- 25-Hydroxyvitamin D and Risk of Myocardial Infarction in MenA Prospective StudyArchives of Internal Medicine, 2008
- High Prevalence of Vitamin D Inadequacy and Implications for HealthMayo Clinic Proceedings, 2006