Retinopathy and attenuated circadian entrainment in Crx-deficient mice
- 1 December 1999
- journal article
- letter
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 23 (4), 466-470
- https://doi.org/10.1038/70591
Abstract
Crx, an Otx-like homeobox gene, is expressed specifically in the photoreceptors of the retina and the pinealocytes of the pineal gland1,2. Crx has been proposed to have a role in the regulation of photoreceptor-specific genes in the eye and of pineal-specific genes in the pineal gland. Mutations in human CRX are associated with the retinal diseases, cone-rod dystrophy-2 (adCRD2; refs 3, 4, 5), retinitis pigmentosa5 (RP) and Leber congenital amaurosis5,6 (LCA), which all lead to loss of vision. We generated mice carrying a targeted disruption of Crx. Crx–/– mice do not elaborate photoreceptor outer segments and lacked rod and cone activity as assayed by electroretinogram (ERG). Expression of several photoreceptor- and pineal-specific genes was reduced in Crx mutants. Circadian entrainment was also affected in Crx–/– mice.Keywords
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