Ethnic minority disparities in progression and mortality of pre-dialysis chronic kidney disease: a systematic scoping review
Open Access
- 9 June 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in BMC Nephrology
- Vol. 21 (1), 1-14
- https://doi.org/10.1186/s12882-020-01852-3
Abstract
There are a growing number of studies on ethnic differences in progression and mortality for pre-dialysis chronic kidney disease (CKD), but this literature has yet to be synthesised, particularly for studies on mortality. This scoping review synthesized existing literature on ethnic differences in progression and mortality for adults with pre-dialysis CKD, explored factors contributing to these differences, and identified gaps in the literature. A comprehensive search strategy using search terms for ethnicity and CKD was taken to identify potentially relevant studies. Nine databases were searched from 1992 to June 2017, with an updated search in February 2020. 8059 articles were identified and screened. Fifty-five studies (2 systematic review, 7 non-systematic reviews, and 46 individual studies) were included in this review. Most were US studies and compared African-American/Afro-Caribbean and Caucasian populations, and fewer studies assessed outcomes for Hispanics and Asians. Most studies reported higher risk of CKD progression in Afro-Caribbean/African-Americans, Hispanics, and Asians, lower risk of mortality for Asians, and mixed findings on risk of mortality for Afro-Caribbean/African-Americans and Hispanics, compared to Caucasians. Biological factors such as hypertension, diabetes, and cardiovascular disease contributed to increased risk of progression for ethnic minorities but did not increase risk of mortality in these groups. Higher rates of renal replacement therapy among ethnic minorities may be partly due to increased risk of progression and reduced mortality in these groups. The review identifies gaps in the literature and highlights a need for a more structured approach by researchers that would allow higher confidence in single studies and better harmonization of data across studies to advance our understanding of CKD progression and mortality.Keywords
Funding Information
- Kidney Research UK (N/A)
This publication has 66 references indexed in Scilit:
- A cohort study on the rate of progression of diabetic chronic kidney disease in different ethnic groupsBMJ Open, 2013
- Association of Hypo- and Hyperkalemia with Disease Progression and Mortality in Males with Chronic Kidney Disease: The Role of RaceNephron Clinical Practice, 2011
- Low 25-Hydroxyvitamin D Levels and Mortality in Non–Dialysis-Dependent CKDAmerican Journal of Kidney Diseases, 2011
- The relationship of ethnicity to the prevalence and management of hypertension and associated chronic kidney diseaseBMC Nephrology, 2011
- Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. A collaborative meta-analysis of kidney disease population cohortsKidney International, 2011
- White/Black Racial Differences in Risk of End-stage Renal Disease and DeathThe American Journal of Medicine, 2009
- MYH9 is associated with nondiabetic end-stage renal disease in African AmericansNature Genetics, 2008
- Racial Differences in Mortality and ESRDAmerican Journal of Kidney Diseases, 2008
- Racial Differences in Mortality Among Those with CKDJournal of the American Society of Nephrology, 2008
- Chronic Kidney Disease Incidence, and Progression to End‐Stage Renal Disease, in HIV‐Infected Individuals: A Tale of Two RacesThe Journal of Infectious Diseases, 2008