Miniature Mass Spectrometers
Top Cited Papers
- 19 July 2009
- journal article
- Published by Annual Reviews in Annual Review of Analytical Chemistry
- Vol. 2 (1), 187-214
- https://doi.org/10.1146/annurev-anchem-060908-155229
Abstract
We discuss miniaturization in mass spectrometry in terms of the mass analyzer, the mass spectrometer, and the total analytical system. Mass analyzer miniaturization has focused on ion traps. Decreases in mass analyzer size facilitate reduction of the sizes of the other components of a miniature mass spectrometer, especially the radio frequency electronics and vacuum system. Appropriate sample introduction systems are needed for performance optimization. The criteria by which a miniature mass spectrometer is judged include adequate performance in the traditional areas of resolution, detection limits, and specificity; ruggedness; reliability; and fully autonomous operation. Our discussion of the total analytical system emphasizes the removal of the bottleneck of sample preparation and suggests a solution to the combination of sampling, preconcentration, and ionization: ambient ionization methods. We also describe current miniature mass spectrometers.Keywords
This publication has 100 references indexed in Scilit:
- Ambient Mass Spectrometry with a Handheld Mass Spectrometer at High PressureAnalytical Chemistry, 2007
- Versatile New Ion Source for the Analysis of Materials in Open Air under Ambient ConditionsAnalytical Chemistry, 2005
- Rectilinear Ion Trap: Concepts, Calculations, and Analytical Performance of a New Mass AnalyzerAnalytical Chemistry, 2004
- Characterization of a serial array of miniature cylindrical ion trap mass analyzersRapid Communications in Mass Spectrometry, 1999
- High-pressure effects in miniature arrays of quadrupole analyzers for residual gas analysis from 10−9 to 10−2 TorrJournal of Vacuum Science & Technology A, 1996
- Laser produced ions stored in a cylindrical ion trap and detected in a reflectron time-of-flight mass spectrometerInternational Journal of Mass Spectrometry and Ion Processes, 1994
- Operation of a quadrupole ion trap mass spectrometer to achieve high mass/charge ratiosInternational Journal of Mass Spectrometry and Ion Processes, 1991
- Direct insertion membrane probe for selective introduction of organic compounds into a mass spectrometerAnalytica Chimica Acta, 1990
- Ion-trapping technique for ion/molecule reaction studies in the center quadrupole of a triple quadrupole mass spectrometerInternational Journal of Mass Spectrometry and Ion Processes, 1988
- Recent improvements in and analytical applications of advanced ion trap technologyInternational Journal of Mass Spectrometry and Ion Processes, 1984