Anti-Inflammatory, Anticholinesterase, and Antioxidant Potential of Scopoletin Isolated fromCanarium patentinerviumMiq. (Burseraceae Kunth)
Open Access
- 25 June 2013
- journal article
- research article
- Published by Hindawi Limited in Evidence-Based Complementary and Alternative Medicine
- Vol. 2013, 1-7
- https://doi.org/10.1155/2013/734824
Abstract
Bioassay guided fractionation of an ethanol extract of leaves ofCanarium patentinerviumMiq. (Burseraceae Kunth.) led to the isolation of scopoletin. The structure of this coumarin was elucidated based on spectroscopic methods including nuclear magnetic resonance (NMR-1D and 2D) and mass spectrometry. Scopoletin inhibited the enzymatic activity of 5-lipoxygenase and acetyl cholinesterase with an IC50equal to μM and mM, respectively, and confronted oxidation in the ABTS, DPPH, FRAP, andβ-carotene bleaching assay with EC50values equal to μM, mM, mM and mM, respectively. Given the aforementioned evidence, it is tempting to speculate that scopoletin represents an exciting scaffold from which to develop leads for treatment of neurodegenerative diseases.
Keywords
This publication has 40 references indexed in Scilit:
- In Vitro Antimicrobial, Antioxidant Activities and Phytochemical Analysis of Canarium patentinervium Miq. from MalaysiaBiotechnology Research International, 2011
- Nitrative and Oxidative Stress in Toxicology and DiseaseToxicological Sciences, 2009
- Effect of 5-LOX/COX-2 common inhibitor DHDMBF30 on pancreatic cancer cell Capan2World Journal of Gastroenterology, 2008
- Antioxidant and cytoprotective activity of leaves of Peltiphyllum peltatum (Torr.) Engl.Food Chemistry, 2007
- Investigations on the essential oil of Cymbopogon giganteus from Benin for its potential use as an anti-inflammatory agentInternational Journal of Aromatherapy, 2006
- Standardized Methods for the Determination of Antioxidant Capacity and Phenolics in Foods and Dietary SupplementsJournal of Agricultural and Food Chemistry, 2005
- The Chemistry behind Antioxidant Capacity AssaysJournal of Agricultural and Food Chemistry, 2005
- Antimicrobial screening of plants used for traditional medicine in the state of Perak, Peninsular MalaysiaFitoterapia, 2004
- Anti-Inflammatory Compounds of Plant Origin. Part I. Action on Arachidonic Acid Pathway, Nitric Oxide and Nuclear Factor κ B (NF-κB)Planta Medica, 2003
- Inhibition of 5-lipoxygenase by essential oils and other natural fragrant extractsInternational Journal of Aromatherapy, 2003