Abrogation of Ref1 Retrovirus Restriction in Human Cells
Open Access
- 1 March 2002
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 76 (5), 2548-2550
- https://doi.org/10.1128/jvi.76.5.2548-2550.2002
Abstract
We have previously described postentry restriction of murine leukemia virus in mammals. Here we characterize the block in human cells. Restricted infection kinetics are multiple hit at high virus dose, and restriction is abrogated by preexposure to restricted virus. We hypothesize that restricted capsid can titrate out the restriction factor.Keywords
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