Interferon-γ, a valuable surrogate marker of Plasmodium falciparum pre-erythrocytic stages protective immunity
Open Access
- 8 February 2011
- journal article
- Published by Springer Science and Business Media LLC in Malaria Journal
- Vol. 10 (1), 27
- https://doi.org/10.1186/1475-2875-10-27
Abstract
Immunity against the pre-erythrocytic stages of malaria is the most promising, as it is strong and fully sterilizing. Yet, the underlying immune effectors against the humanPlasmodium falciparumpre-erythrocytic stages remain surprisingly poorly known and have been little explored, which in turn prevents any rational vaccine progress. Evidence that has been gathered in vitro and in vivo, in higher primates and in humans, is reviewed here, emphasizing the significant role of IFN-γ, either as a critical immune mediator or at least as a valuable surrogate marker of protection. One may hope that these results will trigger investigations in volunteers immunized either by optimally irradiated or over-irradiated sporozoites, to quickly delineate better surrogates of protection, which are essential for the development of a successful malaria vaccine.Keywords
This publication has 78 references indexed in Scilit:
- A retrospective evaluation of the role of T cells in the development of malaria vaccineExperimental Parasitology, 2010
- The role of TNF in parasitic diseases: Still more questions than answersInternational Journal for Parasitology, 2010
- Immunological mechanisms underlying protection mediated by RTS,S: a review of the available dataMalaria Journal, 2009
- Protection against a Malaria Challenge by Sporozoite InoculationNew England Journal of Medicine, 2009
- Clinical malaria vaccine developmentImmunology Letters, 2009
- Protection against Plasmodium falciparum challenge induced in Aotus monkeys by liver‐stage antigen‐3‐derived long synthetic peptidesEuropean Journal of Immunology, 2008
- Genetic Immunisation by Liver Stage Antigen 3 Protects Chimpanzees against Malaria despite Low Immune ResponsesPLOS ONE, 2008
- Starring stellate cells in liver immunologyCurrent Opinion in Immunology, 2008
- Lipopeptide immunization without adjuvant induces potent and long-lasting B, T helper, and cytotoxic T lymphocyte responses against a malaria liver stage antigen in mice and chimpanzeesEuropean Journal of Immunology, 1997
- HLA class I-associated resistance to severe malaria: A parasitological re-assessmentParasitology Today, 1997