Developmental regulation of expression of the α1and α2subunits mRNAs of the voltage-dependent calcium channel in a differentiating myogenic cell line
- 3 July 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 250 (2), 515-518
- https://doi.org/10.1016/0014-5793(89)80787-2
Abstract
The voltage-dependent calcium channel (VDCC) in skeletal muscle probably plays a key role in transducing membrane charge movement to the calcium release channel. We report here that the expression of VDCC α1 and α2 mRNAs is developmentally regulated in differentiating C2Cl2 myogenic cells. The α1 mRNA is not detectable in the myoblast form of C2Cl2 cells while its expression is induced 20-fold in differentiated myotubes. In contrast, the α2 mRNA is weakly expressed in myoblasts but is also induced upon myogenic differentiationKeywords
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