Intracellularly Expressed Single-Domain Antibody against p15 Matrix Protein Prevents the Production of Porcine Retroviruses
Open Access
- 15 November 2003
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 77 (22), 12132-12139
- https://doi.org/10.1128/jvi.77.22.12132-12139.2003
Abstract
The presence of porcine endogenous retroviruses presents a potential risk of transmission of infectious diseases (xenozoonosis) if tissues and organs from genetically modified pigs are to be used in xenotransplantation. Here, we report that intracellular expression of a llama single-domain antibody against p15, the matrix domain protein of the porcine endogenous retrovirus Gag polyprotein, blocks retrovirus production, providing the possibility of eliminating the risk of infection in xenotransplantation.Keywords
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