Association Between Overweight and Obesity and Risk of Clinically Diagnosed Knee, Hip, and Hand Osteoarthritis: A Population‐Based Cohort Study
Top Cited Papers
Open Access
- 5 April 2016
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatology
- Vol. 68 (8), 1869-1875
- https://doi.org/10.1002/art.39707
Abstract
Objective Studies of previous cohorts have demonstrated an association between a status of overweight/obesity and the presence of knee and hand osteoarthritis (OA). However, no data on the effect of these factors on the OA burden are available. The aim of the present study was to analyze the effect of being overweight or obese on the incidence of routinely diagnosed knee, hip, and hand OA. Methods The study was conducted in a population‐based cohort using primary care records from the Sistema d'Informació per al Desenvolupament de l'Investigació en Atenció Primària database (>5.5 million subjects, covering >80% of the population of Catalonia, Spain). Participants were subjects ages ≥40 years who were without a diagnosis of OA on January 1, 2006 and had available body mass index (BMI) data. All subjects were followed up from January 1, 2006 to December 31, 2010 or to the time of loss to follow‐up or death. Measures included the World Health Organization categories of BMI (exposure), and incident clinical diagnoses of knee, hip, or hand OA according to International Classification of Diseases, Tenth Revision codes. Results In total, 1,764,061 subjects were observed for a median follow‐up period of 4.45 years (interquartile range 4.19–4.98 years). Incidence rates (per 1,000 person‐years at risk) of knee, hip, and hand OA were 3.7 (99% confidence interval [99% CI] 3.6–3.8), 1.7 (99% CI 1.7–1.8), and 2.6 (99% CI 2.5–2.7), respectively, among subjects in the normal weight category, and 19.5 (99% CI 19.1–19.9), 3.8 (99% CI 3.7–4.0), and 4.0 (99% CI 3.9–4.2), respectively, in those with a classification of grade II obesity. Compared to subjects with normal weight, being overweight or obese increased the risk of OA at all 3 joint sites, especially at the knee. A status of overweight, grade I obesity, and grade II obesity increased the risk of knee OA by a factor of 2‐fold, 3.1‐fold, and 4.7‐fold, respectively. Conclusion Being overweight or obese increases the risk of hand, hip, and knee OA, with the greatest risk in the knee, and this occurs on a dose‐response gradient of increasing BMI.Keywords
Funding Information
- IDIAP Jordi Gol Primary Care Research Institute (4R15/-15)
- Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford
- MRC Lifecourse Epidemiology Unit Southampton
This publication has 26 references indexed in Scilit:
- Obesity & osteoarthritis2013
- Body mass index and susceptibility to knee osteoarthritis: A systematic review and meta-analysisJoint Bone Spine, 2012
- Life course body mass index and risk of knee osteoarthritis at the age of 53 years: evidence from the 1946 British birth cohort studyAnnals Of The Rheumatic Diseases, 2011
- Construction and validation of a scoring system for the selection of high-quality data in a Spanish population primary care database (SIDIAP)Journal of Innovation in Health Informatics, 2011
- The relationship between body mass index and hip osteoarthritis: A systematic review and meta-analysisJoint Bone Spine, 2011
- Lifetime body mass index, other anthropometric measures of obesity and risk of knee or hip osteoarthritis in the GOAL case-control studyOsteoarthritis and Cartilage, 2011
- Obesity and osteoarthritis in knee, hip and/or hand: An epidemiological study in the general population with 10 years follow-upBMC Musculoskeletal Disorders, 2008
- Incidence of severe knee and hip osteoarthritis in relation to different measures of body mass: a population-based prospective cohort studyAnnals Of The Rheumatic Diseases, 2008
- An investigation of risk factors for symptomatic osteoarthritis of the knee in women using a life course approachJournal of Epidemiology and Community Health, 2003
- Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health careAnnals Of The Rheumatic Diseases, 2001