Cardiovascular Beneficial Effects of Electroacupuncture at Neiguan (PC-6) Acupoint in Anesthetized Open-Chest Dog.
- 1 January 2001
- journal article
- Published by Physiological Society of Japan in The Japanese Journal of Physiology
- Vol. 51 (2), 231-238
- https://doi.org/10.2170/jjphysiol.51.231
Abstract
Neiguan (PC-6) is a traditional acupoint in the bilateral forearms, overlying the median nerve trunk. Neiguan electroacupuncture (EA) has been believed to affect cardiovascular function and used in traditional Chinese medicine to improve or treat a wide range of health conditions and diseases, including angina pectoris, myocardial infarction, hypertension, and hypotension. However, few physiological studies have assessed the beneficial effects of Neiguan EA on the cardiovascular function. In the present study, we investigated its effects on the cardiovascular function in normal open-chest dogs under pentobarbital and fentanyl anesthesia. We also obtained left ventricular (LV) pressure-volume (P-V) data with a micromanometer catheter and a volumetric conductance catheter. Mean arterial pressure, end-diastolic volume, heart rate, stroke volume, cardiac output, and end-systolic pressure gradually decreased by 5 to 10% over 1.5 h without Neiguan EA. Neiguan EA at 40 Hz, however, increased these cardiovascular variables by 10 to 15%, especially end-systolic elastance (Ees) by 40% (p<0.05) over 15 to 60 min. After Neiguan EA was stopped at 1 h, these facilitated cardiovascular variables decreased below the pre-EA level. This beneficial effect of electroacupuncture may contribute to the effectiveness of the acupuncture in Chinese medicine.Keywords
This publication has 10 references indexed in Scilit:
- NO regulates PDGF-induced activation of PKB but not ERK in A7r5 cells: implications for vascular growth arrestAmerican Journal of Physiology-Cell Physiology, 2000
- Effects of Intracoronary Fentanyl on Left Ventricular Mechanoenergetics in the Excised Cross-circulated Canine HeartAnesthesiology, 1997
- Basics of AcupuncturePublished by Springer Science and Business Media LLC ,1995
- A time-course study of the effects of pentobarbital, fentanyl, and morphine chloralose on myocardial mechanicsJournal of Applied Physiology, 1992
- Beta-adrenoceptor antibodies and genetics in dilated cardiomyopathy-- An overview and reviewEuropean Heart Journal, 1991
- Ventricular energeticsPhysiological Reviews, 1990
- Continuous measurement of left ventricular volume in animals and humans by conductance catheter.Circulation, 1984
- The Effect of Acupuncture on Essential HypertensionThe American Journal of Chinese Medicine, 1975
- Role of Muscular Contraction in the Reflex Vascular Responses to Stimulation of Muscle Afferents in the DogCirculation Research, 1973
- Effect on Left Ventricular Performance of Stimulation of an Afferent Nerve from MuscleCirculation Research, 1968