Mutational Analysis of the Enterocin Favorskii Biosynthetic Rearrangement
- 1 March 2002
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 4 (6), 957-960
- https://doi.org/10.1021/ol0255155
Abstract
A mutational analysis of the enterocin biosynthesis genes revealed that the putative oxygenase and the methyltransferase gene products EncM and EncK, respectively, jointly catalyze a biosynthetic Favorskii-like rearrangement. Inactivation of either gene terminated enterocin production and caused the accumulation of four nonrearranged, nonmethylated polyketides. The structure elucidation of the new wailupemycins E−G is reported.Keywords
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