Neuroinflammation and cognitive function in aged mice following minor surgery
- 19 June 2008
- journal article
- Published by Elsevier BV in Experimental Gerontology
- Vol. 43 (9), 840-846
- https://doi.org/10.1016/j.exger.2008.06.004
Abstract
Following surgery, elderly patients often suffer from postoperative cognitive dysfunction (POCD) which can persist long after physical recovery. It is known that surgery-induced tissue damage activates the peripheral innate immune system resulting in the release of inflammatory mediators. Compared to adults, aged animals demonstrate increased neuroinflammation and microglial priming that leads to an exaggerated proinflammatory cytokine response following activation of the peripheral immune system. Therefore, we sought to determine if the immune response to surgical trauma results in increased neuroinflammation and cognitive impairment in aged mice. Adult and aged mice underwent minor abdominal surgery and 24 h later hippocampal cytokines were measured and working memory was assessed in a reversal learning version of the Morris water maze. While adult mice showed no signs of neuroinflammation following surgery, aged mice had significantly increased levels of IL-1β mRNA in the hippocampus. Minor surgery did not result in severe cognitive impairment although aged mice that underwent surgery did tend to perseverate in the old target during reversal testing suggesting reduced cognitive flexibility. Overall these results suggest that minor surgery leads to an exaggerated neuroinflammatory response in aged mice but does not result in significantly impaired performance in the Morris water maze.Keywords
This publication has 43 references indexed in Scilit:
- Aging sensitizes mice to behavioral deficits induced by central HIV-1 gp120Neurobiology of Aging, 2008
- Type and Severity of Cognitive Decline in Older Adults after Noncardiac SurgeryAnesthesiology, 2008
- Uncomplicated general anesthesia in the elderly results in cognitive decline: Does cognitive decline predict morbidity and mortality?Medical Hypotheses, 2007
- Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune systemBrain, Behavior, and Immunity, 2007
- Knockdown of Nurr1 in the rat hippocampus: Implications to spatial discrimination learning and memoryLearning & Memory, 2006
- Morris water maze: procedures for assessing spatial and related forms of learning and memoryNature Protocols, 2006
- Interaction between interferon γ and insulin‐like growth factor‐1 in hippocampus impacts on the ability of rats to sustain long‐term potentiationJournal of Neurochemistry, 2006
- Postoperative delirium in elderly patients after major abdominal surgeryBritish Journal of Surgery, 2005
- Postoperative cognitive dysfunction: true deterioration versus random variationActa Anaesthesiologica Scandinavica, 2004
- Cognitive dysfunction 1–2 years after non‐cardiac surgery in the elderlyActa Anaesthesiologica Scandinavica, 2000