A Calibration-Free Application of Raman Spectroscopy to the Monitoring of Mannitol Crystallization and Its Polymorphic Transformation
- 11 August 2010
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Process Research & Development
- Vol. 14 (5), 1209-1214
- https://doi.org/10.1021/op100142k
Abstract
No abstract availableThis publication has 17 references indexed in Scilit:
- In-line and real-time process monitoring of a freeze drying process using Raman and NIR spectroscopy as complementary process analytical technology (PAT) toolsJournal of Pharmaceutical Sciences, 2009
- Investigation into the subambient behavior of aqueous mannitol solutions using temperature-controlled Raman microscopyEuropean Journal of Pharmaceutics and Biopharmaceutics, 2007
- Implementation of a Process Analytical Technology System in a Freeze-Drying Process Using Raman Spectroscopy for In-Line Process MonitoringAnalytical Chemistry, 2007
- Application of in Situ FBRM and ATR-FTIR to the Monitoring of the Polymorphic Transformation of d-MannitolOrganic Process Research & Development, 2005
- Measuring Free-Energy Difference between Crystal Polymorphs through Eutectic MeltingThe Journal of Physical Chemistry B, 2005
- In Situ Monitoring of Polymorphic TransitionsOrganic Process Research & Development, 2003
- An Investigation Into the Subambient Behavior of Aqueous Mannitol Solutions Using Differential Scanning Calorimetry, Cold Stage Microscopy, and X-Ray DiffractometryJournal of Pharmaceutical Sciences, 2003
- Quantitative analysis of mannitol polymorphs. FT-Raman spectroscopyJournal of Pharmaceutical and Biomedical Analysis, 2002
- Crystallization of Mannitol below Tg′ during Freeze-Drying in Binary and Ternary Aqueous SystemsPharmaceutical Research, 2002
- Physical characterization of polymorphic drugs: an integrated characterization strategyPharmaceutical Science & Technology Today, 1998