Liver enzyme alteration: a guide for clinicians
Top Cited Papers
Open Access
- 1 February 2005
- journal article
- review article
- Published by CMA Impact Inc. in CMAJ : Canadian Medical Association Journal
- Vol. 172 (3), 367-379
- https://doi.org/10.1503/cmaj.1040752
Abstract
ISOLATED ALTERATIONS OF BIOCHEMICAL MARKERS OF LIVER DAMAGE in a seemingly healthy patient can present a challenge for the clinician. In this review we provide a guide to interpreting alterations to liver enzyme levels. The functional anatomy of the liver and pathophysiology of liver enzyme alteration are briefly reviewed. Using a schematic approach that classifies enzyme alterations as predominantly hepatocellular or predominantly cholestatic, we review abnormal enzymatic activity within the 2 subgroups, the most common causes of enzyme alteration and suggested initial investigations.Keywords
This publication has 82 references indexed in Scilit:
- Risk of parenterally transmitted hepatitis following exposure to surgery or other invasive procedures: results from the hepatitis surveillance system in ItalyJournal of Hepatology, 2001
- A model to predict survival in patients with end-stage liver diseaseJournal of Hepatology, 2001
- A Revised Natural History Model for Primary Sclerosing CholangitisMayo Clinic Proceedings, 2000
- International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitisJournal of Hepatology, 1999
- The Temporal Profile of Increased Transaminase Levels in Patients With Acetaminophen-Induced Liver DysfunctionAnnals of Emergency Medicine, 1995
- Alkaline phosphatase isozymes: recent progressClinical Biochemistry, 1990
- What can we learn from analysis of serum bilirubin?Journal of Hepatology, 1986
- Prospective study of clinical and biochemical features of symptomatic choledocholithiasisDigestive Diseases and Sciences, 1986
- Natural History, Clinical Features, and Treatment of Autoimmune HepatitisSeminars in Liver Disease, 1984
- The SGOT/SGPT ratio?An indicator of alcoholic liver diseaseDigestive Diseases and Sciences, 1979