Innate B Cells: the Archetype of Protective Immune Cells
- 1 February 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Clinical Reviews in Allergy & Immunology
- Vol. 58 (1), 92-106
- https://doi.org/10.1007/s12016-019-08748-7
Abstract
The innate B cell (IBC) population is heterogeneous and involved in the primary immune response. IBC functions include a high ability to produce natural antibodies with IgM isotype, the elimination of apoptotic cells, and a capacity to be cognate help to T cells. Among IBC subsets, B-1 cells and marginal zone B cells are the main producers of IgM, act as rapid immune responders that may relocate to follicular lymphoid and differentiate to cytokine and antibody-secreting cells shortly after infection. IBCs functions are highly dependent on their localization site and the nature of their B cell receptor repertoire, suggesting a high plasticity range of different immune responses. In this review, we will describe the nature and functions of the different innate-like B cell subsets, first in mice and then in humans. Besides this, we will emphasize the strong ability of these cells to undertake different protective functions from the first line of defense against pathogens to the regulatory role of the broader immune response.Keywords
This publication has 139 references indexed in Scilit:
- B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleenNature Immunology, 2011
- Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine modelJournal of Allergy and Clinical Immunology, 2010
- Continual signaling is responsible for constitutive ERK phosphorylation in B-1a cellsMolecular Immunology, 2009
- B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell helpin vivoProceedings of the National Academy of Sciences of the United States of America, 2008
- A Regulatory B Cell Subset with a Unique CD1dhiCD5+ Phenotype Controls T Cell-Dependent Inflammatory ResponsesImmunity, 2008
- Lymphotoxin-Mediated Crosstalk between B Cells and Splenic Stroma Promotes the Initial Type I Interferon Response to CytomegalovirusCell Host & Microbe, 2008
- Structure and specificity of lamprey monoclonal antibodiesProceedings of the National Academy of Sciences of the United States of America, 2008
- Follicular shuttling of marginal zone B cells facilitates antigen transportNature Immunology, 2007
- The splenic marginal zone in humans and rodents: an enigmatic compartment and its inhabitantsHistochemistry and Cell Biology, 2006
- Somatic diversification of variable lymphocyte receptors in the agnathan sea lampreyNature, 2004