Cyclosporin A induces erythroid differentiation of K562 cells through p38 MAPK and ERK pathways
- 30 December 2002
- journal article
- Published by Wiley in American Journal of Hematology
- Vol. 72 (1), 67-69
- https://doi.org/10.1002/ajh.10245
Abstract
We studied the effects of cyclosporin A (CsA) on the erythroid differentiation of human erythroid leukemia cell line K562. After K562 was treated with CsA for 4 days, the percentage of hemoglobinized cells was increased by 3.3 times. Because it was reported p38 MAPK (p38) and ERK are involved in erythropoietin‐induced erythroid differentiation, we studied their roles using specific inhibitors. p38 inhibitor (SB203580) prevented CsA‐induced hemoglobin synthesis in K562 cells, although MEK/ERK inhibitor (U0126) enhanced it by 3.3 times in K562 cells. These results indicate activation of p38 and inactivation of ERK are involved in CsA‐induced erythroid differentiation of K562 cells. Am. J. Hematol. 72:67–69, 2003.Keywords
This publication has 6 references indexed in Scilit:
- Manipulating Immune Responses with Immunosuppressive Agents that Target NFATImmunity, 2000
- Butyrate-induced erythroid differentiation of human K562 leukemia cells involves inhibition of ERK and activation of p38 MAP kinase pathwaysBlood, 2000
- Activation of p38 MAP Kinase and JNK But Not ERK Is Required for Erythropoietin-Induced Erythroid DifferentiationBlood, 1998
- Tyrosine 763 of the Murine Granulocyte Colony-Stimulating Factor Receptor Mediates Ras-Dependent Activation of the JNK/SAPK Mitogen-Activated Protein Kinase PathwayMolecular and Cellular Biology, 1997
- Ca2+/Calmodulin-dependent and -independent Down-regulation of c-myb mRNA Levels in Erythropoietin-responsive Murine Erythroleukemia CellsPublished by Elsevier BV ,1996
- Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptorCell, 1995