Intrinsic Functional Relations Between Human Cerebral Cortex and Thalamus
- 1 October 2008
- journal article
- research article
- Published by American Physiological Society in Journal of Neurophysiology
- Vol. 100 (4), 1740-1748
- https://doi.org/10.1152/jn.90463.2008
Abstract
The brain is active even in the absence of explicit stimuli or overt responses. This activity is highly correlated within specific networks of the cerebral cortex when assessed with resting-state functional magnetic resonance imaging (fMRI) blood oxygen level–dependent (BOLD) imaging. The role of the thalamus in this intrinsic activity is unknown despite its critical role in the function of the cerebral cortex. Here we mapped correlations in resting-state activity between the human thalamus and the cerebral cortex in adult humans using fMRI BOLD imaging. Based on this functional measure of intrinsic brain activity we partitioned the thalamus into nuclear groups that correspond well with postmortem human histology and connectional anatomy inferred from nonhuman primates. This structure/function correspondence in resting-state activity was strongest between each cerebral hemisphere and its ipsilateral thalamus. However, each hemisphere was also strongly correlated with the contralateral thalamus, a pattern that is not attributable to known thalamocortical monosynaptic connections. These results extend our understanding of the intrinsic network organization of the human brain to the thalamus and highlight the potential of resting-state fMRI BOLD imaging to elucidate thalamocortical relationships.Keywords
This publication has 59 references indexed in Scilit:
- Loss of Resting Interhemispheric Functional Connectivity after Complete Section of the Corpus CallosumJournal of Neuroscience, 2008
- Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode NetworkCerebral Cortex, 2008
- Inhibition and Brain WorkNeuron, 2007
- Resting-State Functional Connectivity in Major Depression: Abnormally Increased Contributions from Subgenual Cingulate Cortex and ThalamusBiological Psychiatry, 2007
- Distinct brain networks for adaptive and stable task control in humansProceedings of the National Academy of Sciences of the United States of America, 2007
- Network structure of cerebral cortex shapes functional connectivity on multiple time scalesProceedings of the National Academy of Sciences of the United States of America, 2007
- Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive ControlJournal of Neuroscience, 2007
- Consistent resting-state networks across healthy subjectsProceedings of the National Academy of Sciences of the United States of America, 2006
- Effects of sound level on fMRI activation in human brainstem, thalamic and cortical centersHearing Research, 2006
- Registration of [18F]FDG microPET and small-animal MRINuclear Medicine and Biology, 2005