Heparin in the long-term management of ligneous conjunctivitis
- 1 October 2011
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in Blood Coagulation & Fibrinolysis
- Vol. 22 (7), 606-609
- https://doi.org/10.1097/mbc.0b013e3283494b52
Abstract
Ligneous conjunctivitis, secondary to inherited homozygous plasminogen deficiency, is a poorly understood condition that has the potential to hinder normal childhood development if not managed adequately. We report the clinical progression of a child with ligneous conjunctivitis, controlled with daily heparin eye drops, postsurgical excision, for a duration of approximately 5 years at a cost of approximately 30 USD per month. During this time, the patient's progress has been complicated by one occurrence of periorbital cellulitis and also otitis media. The patient has also experienced ocular complications due to the remaining membranous lesion. This case indicates that individual patient factors including plasminogen levels and exposure to triggers of ocular inflammation may influence the clinical progression of ligneous conjunctivitis. Furthermore, this study is one of the first to present over 5-year follow-up of a patient with ligneous conjunctivitis effectively managed with long-term heparin eye drops.Keywords
This publication has 24 references indexed in Scilit:
- The first two Japanese cases of severe type I congenital plasminogen deficiency with ligneous conjunctivitis: Successful treatment with direct thrombin inhibitor and fresh plasmaAmerican Journal of Hematology, 2009
- Plasminogen deficiencyHaemophilia, 2008
- Systemic and Topical Fresh-Frozen Plasma Treatment in a Newborn With Ligneous ConjunctivitisCornea, 2008
- Long-term efficacy of surgical removal of pseudomembranes in a child with ligneous conjunctivitis treated with plasminogen eyedropsThrombosis and Haemostasis, 2008
- Plasminogen deficiencyJournal of Thrombosis and Haemostasis, 2007
- A ligneous periodontitis and conjunctival lesions in a patient with plasminogen deficiencyOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2007
- Ligneous conjunctivitis: a case report with multiorgan involvementHistopathology, 2007
- Molecular and clinical spectrum of type I plasminogen deficiency: a series of 50 patientsBlood, 2006
- Amniotic membrane transplantation in a case of ligneous conjunctivitisAmerican Journal of Ophthalmology, 2004
- Severe prekallikrein (Fletcher factor) deficiency due to a compound heterozygosis (383Trp stop codon and Cys529Tyr)Thrombosis and Haemostasis, 2003