Reduced Serum Levels of Triglyceride, Very Low Density Lipoprotein Cholesterol and Apolipoprotein B in Parkinson’s Disease Patients
Open Access
- 26 September 2013
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 8 (9), e75743
- https://doi.org/10.1371/journal.pone.0075743
Abstract
Previous studies have shown a lower incidence of stroke in Parkinson’s disease (PD) patients. The role of the lipids and lipoproteins as risk factors for stroke is uncertain in the lower prevalence of stroke in PD patients. To explore the lipids and lipoproteins serum levels in PD patients. A retrospective study was performed on 110 PD patients (PD group), 130 controls with non-cerebrovascular neurological diseases (OD group), 140 acute intracerebral hemorrhage patients (ICH group) and 140 acute cerebral infarction patients (CI group). The records about serum levels of lipids and lipoproteins were analyzed. There were significant differences for the serum level of triglyceride (F = 5.031, p=0.002), very low density lipoprotein cholesterol (F = 5.313, p=0.001), apolipoprotein B (F = 16.038, pp=0.032), ICH (p=0.00047) and CI (p=0.001) groups. Very low density lipoprotein cholesterol (VLDL-C) serum level was significantly lower in PD group than in OD (p=0.039), ICH (p=0.00021) and CI (p=0.001) groups. There was a significantly lower serum level of apolipoprotein B (apo B) in PD group than in OD (p=0.002), ICH (pp<0.0001) groups. There are reduced serum levels of TG, VLDL-C and apo B in PD patients, which may be related to the decreased prevalence of stroke in PD patients.Keywords
This publication has 34 references indexed in Scilit:
- Body mass index in Parkinson’s disease: A meta-analysisParkinsonism & Related Disorders, 2012
- Mixed Dyslipidemia, Metabolic Syndrome, Diabetes Mellitus, and Cardiovascular Disease: Clinical ImplicationsThe American Journal of Cardiology, 2008
- Reduced Risk Factors for Vascular Disorders in Parkinson Disease PatientsStroke, 2006
- Apolipoproteins as Predictors of Ischaemic Stroke in Patients with a Previous Transient Ischaemic AttackCerebrovascular Diseases, 2006
- Apolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosisJournal of Internal Medicine, 2005
- Autoantibodies Against Oxidatively Modified LDL Do Not Constitute a Risk Factor for StrokeStroke, 1999
- Stroke and Parkinson's disease.Stroke, 1992
- Hypertension, lipoprotein(a), and apolipoprotein A-I as risk factors for stroke in the Chinese.Stroke, 1991
- Stroke and its modification in Parkinson's disease.Stroke, 1990
- ParkinsonismNeurology, 1967