Metabolic Myopathies and Physical Activity
- 19 June 2002
- journal article
- Published by Informa UK Limited in The Physician and Sportsmedicine
- Vol. 30 (6), 37-46
- https://doi.org/10.3810/psm.2002.06.341
Abstract
Fatigue can have many causes in active people. A metabolic myopathy-though uncommonly identified as a cause of fatigue during sporting events-must be considered in certain circumstances, and the diagnosis may be helpful for preventive and genetic counseling. In general, symptoms of disorders of glycogen breakdown and glucose utilization (glycogen storage diseases) occur during high-intensity exercise. Symptoms of disorders of fatty acid transport or oxidation and mitochondrial disorders occur after endurance exercise. Important investigations include forearm ischemic testing, electromyographic and nerve conduction studies, muscle biopsy (histology, enzyme, and DNA testing), and exercise testing. Most patients with metabolic myopathies can participate in sports with appropriate exercise adaptations and dietary manipulation.Keywords
This publication has 17 references indexed in Scilit:
- Gender differences in muscle inflammation after eccentric exerciseJournal of Applied Physiology, 2000
- THE MOLECULAR DIAGNOSIS OF METABOLIC MYOPATHIESNeurologic Clinics, 2000
- Mitochondrial Disorders: Clinical and Genetic FeaturesAnnual Review of Medicine, 1999
- Naproxen does not alter indices of muscle damage in resistance-exercise trained menMedicine & Science in Sports & Exercise, 1999
- Abnormal oxidative metabolism in exercise in exercise intolerance of undetermined originNeuromuscular Disorders, 1997
- Metabolic myopathiesSeminars in Pediatric Neurology, 1996
- Glycogen Storage Disease in AdultsAnnals of Internal Medicine, 1994
- In vivo muscle magnetic resonance spectroscopy in the clinical investigation of mitochondria1 diseaseNeurology, 1991
- Investigation of human mitochondrial myopathies by phosphorus magnetic resonance spectroscopyAnnals of Neurology, 1985
- Fatigue of long duration in human skeletal muscle after exercise.The Journal of Physiology, 1977