Percutaneous thermal ablation for recurrent hepatocellular carcinoma after hepatectomy
- 25 July 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Surgery
- Vol. 92 (11), 1393-1398
- https://doi.org/10.1002/bjs.5102
Abstract
Background Tumour ablation using a thermal energy source has shown promising results, and is particularly suitable for recurrent hepatocellular carcinoma (HCC). The present study evaluated long-term outcomes after percutaneous thermal ablation for recurrent HCC following liver resection. Methods Radiofrequency ablation or microwave ablation was used to treat a total of 124 tumour nodules (0·9–7·0 cm in diameter) in 72 patients with recurrent HCC. Results Complete ablation of 119 (96·0 per cent) of 124 tumour nodules was achieved. There was no treatment-related death and the major complication rate was 4 per cent. During a mean(s.d.) follow-up of 27·9(17·8) months, local recurrence developed in 16 (13·6 per cent) of 118 successfully treated tumour nodules. Distant recurrence developed in 60 (85 per cent) of 71 patients, of whom 26 had repeat metachronous distant recurrence. With repeated ablation for both local and distant recurrence, the 1-, 3- and 5-year overall survival rates after initial ablation were 75, 43 and 18 per cent respectively. Patients with a serum α-fetoprotein level greater than 200 ng/ml before treatment had significantly poorer survival than those with a lower level (P = 0·034) and multivariate analysis identified preablation AFP level as an independent prognostic factor (P = 0·054). Conclusion With their advantages of preservation of non-tumorous liver tissue and easy repetition, percutaneous thermal ablative therapies were particularly suitable for recurrent HCC and improved long-term survival.Keywords
This publication has 30 references indexed in Scilit:
- Percutaneous Local Ablative Therapy for Hepatocellular CarcinomaAnnals of Surgery, 2003
- Locoregional Therapies for Hepatocellular Carcinoma: A Critical Review From the Surgeon’s PerspectiveAnnals of Surgery, 2002
- Hepatic radiofrequency ablation.Archives of Surgery, 2002
- Repeat hepatectomy is the most useful treatment for recurrent hepatocellular carcinomaJournal of Hepato-Biliary-Pancreatic Surgery, 2001
- Improving Survival Results After Resection of Hepatocellular Carcinoma: A Prospective Study of 377 Patients Over 10 YearsAnnals of Surgery, 2001
- No-Mortality Liver Resection for Hepatocellular Carcinoma in Cirrhotic and Noncirrhotic PatientsArchives of Surgery, 1999
- Intrahepatic Recurrence After Curative Resection of Hepatocellular CarcinomaAnnals of Surgery, 1999
- Repeat hepatectomy for recurrent hepatocellular carcinomaBritish Journal of Surgery, 1996
- Results of 280 Liver Resections for Hepatocellular CarcinomaArchives of Surgery, 1996
- No treatment, resection and ethanol injection in hepatocellular carcinoma: a retrospective analysis of survival in 391 patients with cirrhosisJournal of Hepatology, 1995