Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
- 1 October 1995
- journal article
- Published by Springer Science and Business Media LLC in Nature Medicine
- Vol. 1 (10), 1024-1028
- https://doi.org/10.1038/nm1095-1024
Abstract
Retinopathy of prematurity (ROP) is initiated by hyperoxia-induced obliteration of newly formed blood vessels in the retina of the premature newborn. We propose that vessel regression is a consequence of hyperoxia-induced withdrawal of a critical vascular survival factor. We show that regression of retinal capillaries in neonatal rats exposed to high oxygen, is preceded by a shut-off of vascular endothelial growth factor (VEGF) production by nearby neuroglial cells. Vessel regression occurs via selective apoptosis of endothelial cells. Intraocular injection of VEGF at the onset of experimental hyperoxia prevents apoptotic death of endothelial cells and rescues the retinal vasculature. These findings provide evidence for a specific angiogenic factor acting as a vascular survival factor in vivo. The system also provides a paradigm for vascular remodelling as an adaptive response to an increase in oxygen tension and suggests a novel approach to prevention of ROP.Keywords
This publication has 16 references indexed in Scilit:
- Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal DisordersNew England Journal of Medicine, 1994
- Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.The Journal of cell biology, 1992
- Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesisNature, 1992
- Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivoNature, 1992
- Social controls on cell survival and cell deathNature, 1992
- Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels.The Journal of Experimental Medicine, 1991
- Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGFScience, 1989
- Vascular Endothelial Growth Factor Is a Secreted Angiogenic MitogenScience, 1989
- STUDIES ON DEVELOPING RETINAL VESSELS VIII. EFFECT OF OXYGEN ON THE RETINAL VESSELS OF THE RATLINGBritish Journal of Ophthalmology, 1961
- Effect of Oxygen on Developing Retinal Vessels with Particular Reference to the Problem of Retrolental FibroplasiaBritish Journal of Ophthalmology, 1954