Promiscuity and the single receptor: NKG2D
- 3 August 2007
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Immunology
- Vol. 7 (9), 737-744
- https://doi.org/10.1038/nri2144
Abstract
NKG2D (natural-killer group 2, member D) is a powerful activating receptor expressed by natural killer (NK) cells and T cells that regulates immune responses during infection, cancer and autoimmunity. NKG2D ligands comprise a diverse array of MHC-class-I-related proteins that are upregulated by cellular stress. Why is it beneficial for the host to have so many ligands for the same receptor? In this Opinion article, we propose that although competition with viruses is the most likely evolutionary drive for this diversity, there might be other explanations.Keywords
This publication has 96 references indexed in Scilit:
- The Switch from Latent to Productive Infection in Epstein-Barr Virus-Infected B Cells Is Associated with Sensitization to NK Cell KillingJournal of Virology, 2007
- Expression and function of NKG2D in CD4+ T cells specific for human cytomegalovirusEuropean Journal of Immunology, 2006
- The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60The Journal of Experimental Medicine, 2006
- Positive selection in the evolution of cancerBiological Reviews, 2006
- Regulation of NKG2D Ligand Gene ExpressionHuman Immunology, 2006
- A Scan for Positively Selected Genes in the Genomes of Humans and ChimpanzeesPLoS Biology, 2005
- Selective Down-Regulation of the NKG2D Ligand H60 by Mouse Cytomegalovirus m155 GlycoproteinJournal of Virology, 2005
- A Novel Secreted Tumor Antigen with a Glycosylphosphatidylinositol-Anchored Structure Ubiquitously Expressed in Human CancersBiochemical and Biophysical Research Communications, 2001
- A new polymorphic and multicopy MHC gene family related to nonmammalian class IImmunogenetics, 1994
- In search of the ‘missing self’: MHC molecules and NK cell recognitionImmunology Today, 1990