Differential body weight and feeding responses to high-fat diets in rats and mice lacking cholecystokinin 1 receptors
- 1 July 2007
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Vol. 293 (1), R55-R63
- https://doi.org/10.1152/ajpregu.00002.2007
Abstract
Prior data demonstrated differential roles for cholecystokinin (CCK)1 receptors in maintaining energy balance in rats and mice. CCK1 receptor deficiency results in hyperphagia and obesity of Otsuka Long-Evans Tokushima Fatty (OLETF) rats but not in mice. To ascertain the role of CCK1 receptors in high-fat-diet (HFD)-induced obesity, we compared alterations in food intake, body weight, fat mass, plasma glucose, and leptin levels, and patterns of hypothalamic gene expression in OLETF rats and mice lacking CCK1 receptors in response to a 10-wk exposure to HFD. Compared with Long-Evans Tokushima Otsuka (LETO) control rats, OLETF rats on HFD had sustained overconsumption over the 10-wk period. High fat feeding resulted in greater increases in body weight and plasma leptin levels in OLETF than in LETO rats. In situ hybridization determinations revealed that, while HFD reduced neuropeptide Y (NPY) mRNA expression in both the arcuate nucleus (Arc) and the dorsomedial hypothalamus (DMH) of LETO rats, HFD resulted in decreased NPY expression in the Arc but not in the DMH of OLETF rats. In contrast to these results in OLETF rats, HFD increased food intake and induced obesity to an equal degree in both wild-type and CCK1 receptor−/− mice. NPY gene expression was decreased in the Arc in response to HFD, but was not detectable in the DMH in both wild-type and CCK1 receptor−/− mice. Together, these data provide further evidence for differential roles of CCK1 receptors in the controls of food intake and body weight in rats and mice.Keywords
This publication has 35 references indexed in Scilit:
- Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic AreaNeuron, 1999
- The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weightJCI Insight, 1999
- Role of leptin in the neuroendocrine response to fastingNature, 1996
- Satiating Effect of CholecystokininaAnnals of the New York Academy of Sciences, 1994
- Devazepide antagonizes the inhibitory effect of cholecystokinin on intake in sham-feeding ratsPharmacology Biochemistry and Behavior, 1992
- Hypothalamic neuropeptide Y disturbances in the obese (cp/cp) JCR:LA corpulent ratPeptides, 1992
- Effects of selective cholecystokinin antagonists L364,718 and L365,260 on food intake in ratsPeptides, 1991
- Evidence that decreased feeding induced by systemic injection of cholecystokinin is mediated by CCK-A receptorsEuropean Journal of Pharmacology, 1989
- AChE-stained horizontal sections of the rat brain in stereotaxic coordinatesJournal of Neuroscience Methods, 1980
- Cholecystokinin elicits the complete behavioral sequence of satiety in rats.Journal of Comparative and Physiological Psychology, 1975