Body Adiposity, Insulin, and Leptin in Subgroups of Peruvian Amerindians
- 1 March 2004
- journal article
- research article
- Published by Mary Ann Liebert Inc in High Altitude Medicine & Biology
- Vol. 5 (1), 27-31
- https://doi.org/10.1089/152702904322963663
Abstract
Migration of aboriginal populations is thought to increase the risk of obesity and associated disorders. In this study, we examined body adiposity, glucose, insulin, leptin, and blood pressure in adult Quechua females living in rural villages in the Cuzco region [n = 105, age 35 ± 10 yr (SD) years] and after migration to Lima from Peruvian Central Andes (n = 105, age 37 ± 10 yr). The two populations are of the same origin and have similar fat composition in their diet, but they differ in degree of physical activity (high in Cuzco, low in Lima) and altitude of living (highland in Cuzco, lowland in Lima). The two groups had similar BMI (24.6 ± 3.9 kg/m2 in Cuzco vs. 25.1 ± 4.7 kg/m2 in Lima) and waist circumference (83.1 ± 9.8 cm in Cuzco vs. 83.7 ± 10.6 cm in Lima). Yet women in Lima had increased body fat mass (17.7 ± 5.3 kg in Cuzco vs. 21.5 ± 5.8 kg in Lima, p < 0.001) and higher diastolic blood pressure, glucose, insulin, and leptin (all p < 0.001). Also the HOMA assessment of insulin resistance was higher in Lima (p < 0.001). We conclude that migration of Peruvian Amerindian women from the Cuzco region to Lima is associated with increased risk for obesity and cardiovascular diseases without being associated with higher BMI and waist circumference.Keywords
This publication has 12 references indexed in Scilit:
- Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or MetforminThe New England Journal of Medicine, 2002
- Low prevalence of type 2 diabetes despite a high average body mass index in the aymara natives from chileNutrition, 2001
- Overweight is associated with lower serum leptin in Peruvian Indian than in Caucasian women: A dissociation contributing to low blood pressure?Metabolism, 2001
- Fasting Insulin Levels Influence Plasma Leptin Levels Independently from the Contribution of Adiposity: Evidence from Both a Cross-Sectional and an Intervention StudyJournal of Clinical Endocrinology & Metabolism, 2000
- Leptin is associated with increased risk of myocardial infarctionJournal of Internal Medicine, 1999
- No excess 12-year mortality in men with impaired glucose tolerance who participated in the Malmö Preventive Trial with diet and exerciseDiabetologia, 1998
- Effects of Diet and Exercise in Preventing NIDDM in People With Impaired Glucose Tolerance: The Da Qing IGT and Diabetes StudyDiabetes Care, 1997
- Lack of Diabetes in Rural Colombian AmerindiansDiabetes Care, 1996
- Determinants of Diabetes Mellitus in the Pima IndiansDiabetes Care, 1993
- Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in manDiabetologia, 1985