Breast cancer leptomeningeal metastasis: propensity of breast cancer subtypes for leptomeninges and the analysis of factors influencing survival
Open Access
- 16 January 2013
- journal article
- research article
- Published by Springer Science and Business Media LLC in Medical Oncology
- Vol. 30 (1), 1-8
- https://doi.org/10.1007/s12032-012-0408-4
Abstract
The aim of the study was to define biological subtypes of breast cancer that have the propensity to metastasize to the leptomeninges and to assess factors influencing survival from detection of leptomeningeal metastatis (LM). One hundred and eighteen consecutive breast cancer patients with LM were treated in one institution, between the years 1999 and 2009; 40.5 % of patients had triple-negative subtype, 37.5 % had luminal A subtype and 22 % had HER2-positive subtypes (luminal B and HER2). Of patients with LM, 35 % had lobular cancer. Median survival from the detection of LM was 18 weeks, and 1-year survival was 16 %. Cox multivariate analysis revealed that performance status and systemic treatment statistically significantly influenced survival of patients with LM. Triple-negative biological subtype and lobular histological type of breast cancer had the propensity to metastasize to the leptomeninges. Performance status and systemic treatment ordered after detection of LM statistically significantly influenced survival.Keywords
This publication has 33 references indexed in Scilit:
- Neoplastic Meningitis from Solid Tumors: New Diagnostic and Therapeutic ApproachesThe Oncologist, 2011
- Leptomeningeal metastases from breast cancer: intrinsic subtypes may affect unique clinical manifestationsBreast Cancer Research and Treatment, 2011
- Breast cancer subtypes and response to systemic treatment after whole‐brain radiotherapy in patients with brain metastasesCancer, 2010
- Survival of breast cancer patients with meningeal carcinomatosisAnnals Of Oncology, 2010
- Breast cancer brain metastases: differences in survival depending on biological subtype, RPA RTOG prognostic class and systemic treatment after whole-brain radiotherapy (WBRT)Annals Of Oncology, 2009
- Sites of distant recurrence and clinical outcomes in patients with metastatic triple‐negative breast cancerCancer, 2008
- Triple negative tumours: a critical reviewHistopathology, 2007
- Clinicopathologic characteristics and prognostic factors in 420 metastatic breast cancer patients with central nervous system metastasisCancer, 2007
- The relevance of intraventricular chemotherapy for leptomeningeal metastasis in breast cancer: a randomised studyEuropean Journal Of Cancer, 2004
- Durable response of breast cancer leptomeningeal metastasis to capecitabine monotherapyNeuro-Oncology, 2004