Anti‐obese property of fucoxanthin is partly mediated by altering lipid‐regulating enzymes and uncoupling proteins of visceral adipose tissue in mice
- 4 December 2009
- journal article
- research article
- Published by Wiley in Molecular Nutrition & Food Research
- Vol. 53 (12), 1603-1611
- https://doi.org/10.1002/mnfr.200900079
Abstract
This study investigated the anti-obesity effects of fucoxanthin in diet-induced obesity mice fed a high-fat diet (20% fat, wt/wt). The mice were supplemented with two doses of fucoxanthin (0.05 and 0.2%, wt/wt) for 6 wk. Fucoxanthin significantly lowered body weight and visceral fat-pads weights compared with the control group without altering food intake. In epididymal adipose tissue of fucoxanthin-fed mice, adipocyte sizes and mRNA expression of lipogenic and fatty acid β-oxidation enzymes were significantly altered in a dose-dependent manner. Plasma leptin level was significantly lower in the fucoxanthin groups than in the control group, while the adiponectin level was elevated. Fucoxanthin significantly down-regulated various lipogenic enzyme activities in epididymal adipose tissue with a simultaneous decrease in fatty acid β-oxidation activity. The 0.2% fucoxanthin supplement led to increase mRNA expression of uncoupling protein-1 (UCP-1) and UCP-3 in brown adipose tissue and that of UCP-2 in the epididymal white adipose tissue. However, the 0.05% fucoxanthin only elevated UCP-1 mRNA expression in epididymal white adipose tissue. These results suggest that the anti-obesity effect of fucoxanthin could be mediated by altering lipid-regulating enzymes and UCPs in the visceral fat tissues and plasma adipokine levels.Keywords
This publication has 43 references indexed in Scilit:
- Fructose and the Metabolic Syndrome: Pathophysiology and Molecular MechanismsPublished by Oxford University Press (OUP) ,2008
- Developmental Origin of Fat: Tracking Obesity to Its SourceCell, 2007
- Fructose and the Metabolic Syndrome: Pathophysiology and Molecular MechanismsNutrition Reviews, 2007
- Is visceral obesity the cause of the metabolic syndrome?Annals of Medicine, 2006
- Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa ratsJournal of Lipid Research, 2005
- Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodMethods, 2001
- Rodent obesity models: An overviewExperimental and Clinical Endocrinology & Diabetes, 2001
- Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db MiceCell, 1996
- Development of obesity in transgenic mice after genetic ablation of brown adipose tissueNature, 1993
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry, 1976